Daegu-gyeongbuk Medical Innovation Foundation

Voronoi Inc.

Lg Chem, Ltd

Korea Institute of Science and Technology

Korea Research Institute of Bioscience and Biotechnology

Daegu Gyeongbuk Institute of Science and Technology

National Cancer Center

Samsung Life Public Welfare Foundation

Yi Kyung Ko

Hwan Geun Choi

Jung Beom Son

Nam Doo Kim

So Young Kim

Seock Yong Kang

Eunhwa Ko

Jin-Hee Park

Sun-Hwa Lee

Youn Ho Lee

Dayea Kim

Sun Joo Lee

Se In Kang

Sang Bum Kim

Hee Yoon Ryu

Joong-heui Cho

Eunmi Hong

Seung Min Lee

Tae Bo Sim

Seung Hoon Lee

Seung Su Kim

Young Kwan Kim

Do-Hyun Nam

Jong Bae Park

Hwan Oh Kim

Seungyeon Lee

Eun Hwa Ko

Ju Hee Kang

Jae Hyun Bae

Suk Kyoon Yoon

Ho Jong Yoon

Woo Young Hur

Hyun Kyoung Kim

Chi Man Song

Han Na Cho

Seung Hye Choi

Sungchan Cho

Miri Choi

Seung Yeon Lee

Sang Hyun Min

Kyu-Sun Lee

Sangbum Kim

Sun Hwa Lee

Ji Yoon Seok

Yunho Lee

Kweon Yu

Joong Heui Cho

Ja Wook Koo

Ohhwan Kwon

Heedong Park

Hyang-Sook Hoe

Junggyu Park

Shinae Kim

Joongheui Cho

Hyunkyoung Kim

Younho Lee

Seongho Hong

Tae-ho Jang

Sungwoo Lee

Dong Kyu Choi

Tae-Ho Jang

Jaeyoung Song

Dong Keun Hwang

Joong-Heui Cho

Da Eun Kim

Min Seok Ryu

Ah Reum Han

The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.

Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component

The present invention relates to a novel compound exhibiting enteropeptidase-inhibiting activity, a pharmaceutically acceptable salt thereof, a pharmaceutical composition for preventing and treating metabolic diseases such as obesity, diabetes mellitus or hyperlipidemia, etc. comprising the compound or pharmaceutically acceptable salt, and a method for preventing or treating metabolic disease using the above novel compound. The compound of the present invention has excellent inhibitory activity against enteropeptidase, and thus is not absorbed into the body, but are excreted outside the body. However, since not only fat but also protein are discharged together, it has few side effects such as fat stools and acts only in the gastrointestinal tract, so it has few side effects such as depression, and is very useful as a therapeutic or prophylactic drug for various metabolic diseases such as obesity, diabetes mellitus, and hyperlipidemia.

Compound exhibiting enteropeptidase inhibitory activity

The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases. 

Pyrrolo-pyrimidine derivative compound, preparation method therefor, and pharmaceutical composition comprising same compound as effective ingredient for preventing or treating protein kinase-related disease

The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases

The present invention relates to a novel imidazopyridine derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof and a pharmaceutically acceptable salt thereof can effectively inhibit cancer-related kinases, are excellent in inhibiting proliferation of cancer cells in a cancer cell line, and effectively inhibit proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful as a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. Also, the novel imidazopyridine derivative according to the present invention, the stereoisomer thereof, and the pharmaceutically acceptable salt thereof can effectively inhibit Src and Fyn, thereby being useful as a pharmaceutical composition for preventing or treating the Src and Fyn related diseases, and in particular, have been confirmed to be useful in diabetic nephropathy in animal model experiments. Therefore, the compound of the present invention can be effective as a pharmaceutical composition containing the same as an active ingredient for preventing or treating diabetic nephropathy.

Imidazopyridine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for preventing or treating cancer

The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.

2,3,5-substituted thiophene compound as protein kinase inhibitor

Growing community of inventors

Daegu, South Korea

Yi Kyung Ko