Industrial Technology Research Institute

Yi-Ju Ko

Li-Wen Chang

Ping-Fu Cheng

Maggie Lu

Maggie J M Lu

Chun-Min Liu

Hsiang-Fa Liang

On Lee

Jenn-Tsang Hwang

Felice Cheng

Min-Ying Lin

Chi-Y Hung

Chia-Yu Fan

Shuen-Hsiang Chou

May-Hua Chang

Jheng-Sian Li

Shing-Ming Cheng

A linker-drug represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), C is a conjugator, L is a linker unit, D is a toxin unit, and n is an integer ranging from 1 to 4. The structure of the conjugator is represented by formula (II). In formula (II), X is a leaving group, each of Rand Ris independently a single bond or &#x2014;NH&#x2014;, and Z is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or a combination thereof. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. An antibody-drug conjugate (ADC) employing the above linker-drug is also provided. 

Linker-drug and antibody-drug conjugate (ADC) employing the same

An antibody-drug conjugate (ADC) of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), p is an integer ranging from 1 to 26, A is an antibody, and -(L-D) is a linker-drug unit. L is a linker unit having a glycopeptide, and D is a drug unit. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. A method for forming an antibody-drug conjugate (ADC) is also provided.A-(L-D)&#x2003;&#x2003;(I)

Antibody-drug conjugate (ADC) and method for forming the same

The disclosure provides a recipe for in-situ gel, formed by dissolving at least one polymer and at least one gel prevention agent in a polar solvent to form a solution and placing the solution in a condition for in-situ forming gels. The disclosure also provides an implant and a drug delivery system formed by the recipe.

Recipe for in-situ gel, and implant, drug delivery system formed thereby

An isolated peptide including an amino acid sequence of SEQ ID NO: 1 is provided. The disclosure also provides a delivery system comprising a carrier having a surface, a drug or a dye encapsulated in the carrier, and the disclosed peptide (having an amino acid sequence of SEQ ID NO: 1) grafted on the surface of the carrier.

Peptide for transmigration across blood brain barrier and delivery systems comprising the same

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Taipei, Taiwan

Yi-Ju Ko