Advpharma, Inc.

Yi-Jen Lee

Pan-Chyr Yang

Tse-Ming Hong

Jeremy J W Chen

Cheng-Chung Wu

Jin-Yuan Shin

Harn-Jing Terng

Woan-Jen Lee

The present invention discloses a method for treating cancer by using hCRMP1 and/or active fragments thereof, as well as the active fragments of hCRMP1 that are capable of inhibiting cell proliferation, invasive activity, and metastasis of cancer. The method can also be used prior to, or in combination with, the administration a chemotherapy agent. A vector capable of expressing an hCRMP1, a variant of hCRMP1, a fragment of hCRMP1 or a variant of a fragment of hCRMP1 is also disclosed.

Compositions and methods of using CRMP-1 and its fragments for treating cancer

This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to enhance the expression of the CRMP-1 and/or a reporter protein. The invention also provides a DNA construct containing this transcription unit which can be transfected into a host cell. Additionally, the invention provides methods to enhance the expression of CRMP-1 and/or the reporter protein. The over-expression of CRMP-1 in a cancer cell can inhibit the metastasis of the cancer cell.

Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences

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Hou-Bi Tainan, Taiwan

Yi-Jen Lee