Newave Pharmaceutical Inc.

Amgen Inc.

Massachusetts Institute of Technology

Hoffmann-la Roche Inc.

Lifecell Corporation

Purdue Pharmaceutical Products L.p.

Midea Group Co., Ltd.

Merck Sharp + Dohme Corp.

Nordyne, Inc.

Wd Media, LLC

Merck Sharpe & Dohme Corp.

Euro-celtique S.a.

Emisphere Technologies, Inc.

F. Hoffmann-la Roche Ag

Melinta Therapeutics, Inc.

Yi Heng Chen

Yan Lou

Timothy David Cushing

Xiao He

Xiaolin Hao

Youngsook Shin

Robert Michael Rzasa

Kin-Chun Thomas Luk

Dawei Zhang

Yu Cheng Chen

Hui Xu

Ian W Hunter

Felix Gonzalez Lopez De Turiso

Jin-Jun Liu

Jason A Duquette

Robert Samuel Langer

Daniel Griffith Anderson

Arturo Jose Vegas

Yizhou Dong

Wenquan Sun

Christopher D Prest

Jiacheng Zhou

Mark E Fraley

Lawrence R McGee

Kevin Thomas Love

Steven Gregory Mischke

Binh Vu

Xin-Jie Chu

Jay J Farmer

Sung-Sau So

Craig A Stump

Matthew Irvine Brown

Joseph M Salvino

Brian S Tryon

Paul Christopher Dorsey

Ashoke Bhattacharjee

Douglas C Beshore

Ping Liu

Shili Chen

Peter Michael Wovkulich

Paige Erin Mahaney

David Gschneidner

Michael G Johnson

Chun Sing Li

Kelly Sullivan Kraft

Robert Alan Goodnow, Jr

Harold B Wood

Vatee Pattaropong

Helen J Mitchell

Jennifer L Seganish

Andreas Reichelt

Li Ting Huang

Apostolos Dermatakis

Delai Chen

Akinleye C Alabi

Yunlong Zhang

Brian Stuart Lucas

Hua Wan

Eric Stec

Romyr Dominique

Christophe Michoud

Hongju Li

Brian Gregory Lucas

Allan J Reifel

Thanh Huy Ha

Jie Chen

Barbara Joyce-Shaikh

Pamela Loreen Rossman

Dongfang Meng

Kang Le

Jennifer N Tran

Wendy Lea Corbett

Shaoqing Chen

Rongliang Lou

Adegboyega K Oyelere

Kai-Roy Wang

Joel A Goldberg

Yusheng Wu

Lei He

Minna Bui

Roger Hanselmann

Todd J Kohn

Qinghua Mao

David Joseph Bartkovitz

Keith P Moore

Daniel J Cua

Emily Aijun Liu

Julia Winslow Lohman

Isabel Yang

Xu-Fang Zhang

Swati P Mercer

Jianping Cai

N Catherine Hogan

Dane M Springer

Andrzej Robert Daniewski

Zhiqi Qi

Zhicai Ou

Benjamin Fisher

Nimesh Kabaria

Marek Michal Kabat

The disclosure includes compounds of Formula (A): wherein R, R, R, R, R, R, R, R, R, R, R, and R, j, k, m, n, Y, W, W, W, W, V, L, Z, Q, Q, Q, and Q, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a neorodegenerative disease with these compounds.

Condensed heterocyclic derivates as BCL-2 inhibitors for the treatment of neoplastic diseases

An electronic device such as a wristwatch may include a conductive housing. A corrosion-resistant coating may be deposited on the conductive housing. The coating may include transition layers and an uppermost alloy layer. The transition layers may include a chromium seed layer on the conductive housing and a chromium nitride layer on the chromium seed layer. The uppermost alloy layer may include TiCrCN or other alloys and may provide the coating with desired optical reflection and absorption characteristics. The transition layers may include a minimal number of coating defects, thereby eliminating potential sites at which visible defects could form when exposed to salt water. This may allow the electronic device to exhibit a desired color and to be submerged in salt water without producing undesirable visible defects on the conductive housing structures.

Electronic devices having corrosion-resistant coatings

The disclosure includes compounds of Formula (A), wherein R, R, R, R, R, R, R, R, R, R, and R, h, j, m, n, k, v, s, g, V, W, L, Z, Q, Q, Q, Q, Q, Q, and Q, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a neorodegenerative disease with these compounds.

BCL-2 inhibitors

A method and system for capturing, by a camera a sequence of frames at respective locations within a portion of an environment; capturing, by an inertial measurement unit, a sequence of inertial odometry data corresponding to the sequence of frames at the respective locations; storing in a queue a data record includes information extracted from processing the respective frame and information from the inertial measurement unit; in accordance with a determination that the sequence of inertial odometry data satisfies a first criterion: calculating a first relative pose between the first frame and the second frame; and in accordance with a determination that a difference between the first relative pose and the information extracted from processing the respective frame satisfy a first threshold: generating an initial map of the portion of the environment based on the first data record and the second data record.

Fast and robust initialization method for feature-based monocular visual SLAM using inertial odometry assistance

The disclosure includes compounds of Formula (I)

Substituted pyrazines as inhibitors of BTK, and mutants thereof

The present invention provides antibodies and antigen-binding fragments thereof that bind PI16 and block binding of ILT3 to PI16.

P116 antibodies

The disclosure includes compounds of Formula (A):

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Methods and compounds for restoring mutant p53 function

The method and system disclosed herein presents a method and system for capturing, by a camera disposed on a device moving in an environment, a plurality of image frames recorded in a first coordinate reference frame at respective locations within a portion of the environment in a first time period; capturing, by an inertial measurement unit disposed on the device, sets of inertial odometry data recorded in a second coordinate reference frame; determining a rotational transformation matrix that corresponds to a relative rotation between the first reference frame and the second reference frame; and determining a scale factor from the matching pairs of image frames. The rotational transformation matrix defines an orientation of the device, and the scale factor and the rotational transformation matrix calibrate the plurality of image frames captured by the camera.

Method and apparatus for scale calibration and optimization of a monocular visual-inertial localization system

The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance.

Transglutaminase treated products

The disclosure includes compounds of Formula (A): wherein R, R, R, R, R, R, R, R, R, R, R, and R, j, k, m, n, Y, W, W, W, W, V, L, Z, Q, Q, Q, and Q, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a neurodegenerative disease with these compounds.

The method and device disclosed herein presents a method that includes capturing, by an optical sensor disposed on a device moving in an environment, a plurality of optical data at respective locations within a portion of the environment; capturing, by a wheel encoder disposed on the device, a set of encoder data corresponding to the plurality of optical data at the respective locations; determining a first relative motion based on the plurality of optical data; determining a corresponding second relative motion based on the set of encoder data. In accordance with determining that a difference between the first relative motion and the corresponding second relative motion is larger than a first threshold: increasing a counter indicating a slip event of the wheel encoder. The slip event corresponds to a wheel of the device advancing and the corresponding second relative motion being below a second threshold.

Method and apparatus for optimization of a monocular visual-inertial localization system

The disclosure includes compounds of Formula (I) 

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Whippany, NJ, United States of America

Yi Heng Chen