Shanghai Huachang Environmental Protection Co., Ltd.

Engineering Technology Research Center, Fushun Mining Group Co., Ltd.

Shanghai Jmt-Bio Technology Co., Ltd.

Shanghai Phaarmaceuticals Holding Co., Ltd.

Shanghai Pharmaceuticals Holding Co., Ltd.

Yi Fan

Jian Wang

Jing Jing Zhang

Tao Li

Fei Zhao

Hong Xu

Jing Zhang

Ling Shen

Hualin Wang

Rui Bai

Qiang Yang

Kai Long

Jiangang Wang

Yu Hao

Xin Cui

Na Chen

Yuan Huang

Gongsheng Li

Yuji Wang

Mingfu Bao

Dasong Xing

Da Zhao

Rongpu Zhang

Liping Song

Xiaotian Cui

Jianxin Yu

Haixiang Wu

Jiana Jia

Ganliang Zhang

Leduo Zhang

Yisha She

Zhenying Liu

Provided is a bispecific recombinant protein, comprising a high affinity tumor-targeting arm and a low affinity fusion protein blocking the interaction of CD47 with SIRP&#x3b1;. The antibody corresponding to the high affinity tumor-targeting arm does not bind to CD47, and its binding affinity to the target antigen on the tumor cell is at least 6 times as great as the binding affinity of monomer fusion protein homodimer corresponding to the low affinity fusion protein blocking the interaction of CD47 with SIRP&#x3b1;, to a CD47 on the tumor cell, wherein the low affinity fusion protein blocking the interaction of CD47 with SIRP&#x3b1; comprises a SIRP&#x3b1; extracellular truncation. Also provided are nucleic acid molecules encoding recombinant proteins and the use of the recombinant proteins and nucleic acid molecules in the manufacture of a medicament for treating tumors.

Bispecific recombinant protein and use thereof

Disclosed is a salt of a quinoline derivative, polymorphic forms thereof, preparation methods thereof, a composition, and applications. The SPH1772 ditartrate or crystal form A thereof expresses the following excellent properties: high stability, great bioavailability, excellent pharmacokinetic properties, and better in vivo efficacy than SPH1772 free base.

Salt of quinolone compound, polymorphs thereof, preparation method therefor, composition, and applications

The present invention relates to a method and a device for enclosed recycling of oil-water-sludge in an oil shale dry distillation system, comprising: scrubbing and condensing oil shale dry distillation gas at a gathering pipe section, a gas tower section, an air tower section, and a cooling tower section respectively to recycle shale oil section by section; using a separator at an outlet of each section to purify and collect the shale oil, while purifying and recycling scrubbing/cooling water; using multistage dedusters to remove oil sludge entrained in an oil-water product; using an oil sludge collecting tank and a filter after the deduster to concentrate and recycle an oil sludge; and using cyclones before and after the gas tower section to remove aerosol particles and water drops entrained in circulatory gas. Advantages include: low equipment investment costs, small occupation area, low failure rate, a highly pure shale oil product and a highly concentrated oil sludge product, and recycled waste water generated in the purification and concentration processes, thereby achieving full enclosure of the device system, greatly reducing the energy consumption, and improving the oil shale dry distillation process in the prior art.

Method for enclosed recycling of oil-water-sludge in oil shale dry distillation system

Growing community of inventors

Shanghai, China

Yi Fan