Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan

Institute of Nuclear Energy Research, Atomic Energy Council

Yi-Chih Hsia

Lie-Hang Shen

Kung-Tien Liu

Chia-Chieh Chen

Mei-Hsiu Liao

Ming-Yu Chao

Hang-Hsing Yang

Chang-Yung Su

Shih-Woei Yeh

Tai-Sheng Lin

Lee-Chung Men

The present invention is related to a direct solid sample analytical technology for determining a content and a uniformity thereof in a lyophilized kit of a sulfur-containing chelator with a stable complex capacity for radiotechnetium (Tc-99m) and radiorhenium (Re-186, Re-188). An economical, stable and easily accessible coal standard is used herein as a contrast substance to construct a sulfur calibration curve, followed by obtaining the sulfur content and the uniformity thereof in the solid lyophilized sample by interpolating the foregoing result into the sulfur calibration curve. Then, the weight content percent is converted to get the content and the uniformity of the chelator in the lyophilized kit. The quality control of active pharmaceutical ingredients (API) in the lyophilized kit during key production processes and clinical applications is thus assured.

Direct solid sample analytical technology for determining a content and a uniformity thereof in a lyophilized kit of a sulfur-containing chelator with a stable complex capacity for radiotechnetium (Tc-99M) and radiorhenium (Re-186, Re-188)

An analytical technique for determining the structures of serotonin transporter (SERT) imaging agent [I] ADAM and its precursor, SnADAM by using a high-performance liquid chromatography tandem mass spectrometer (LC-MS/MS) is provided. An analytical technique for determining the purity of SnADAM by using a high-performance liquid chromatograph (HPLC) is also provided.

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Growing community of inventors

Taoyuan County, Taiwan

Yi-Chih Hsia