Ohio University

Yi Cai

Hao Chen

An apparatus () for coupling liquid chromatography with mass spectrometry and for splitting and analyzing a liquid sample includes a fluid conduit (), which defines a flow passage () and is configured to supply the liquid sample. The fluid conduit () has an outer surface and a micro-hole () through the outer surface into the flow passage (). The apparatus () also includes an ambient ionizer () configured to generate and direct a charged solvent () toward the micro-hole () at the outer surface for ionizing a portion of the liquid sample () that emerges out of the micro-hole (). The apparatus () further includes a mass spectrometer () having a sample entrance () adjacent the micro-hole () configured to analyze an ionized portion of the liquid sample ().

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Athens, OH, United States of America

Yi Cai