Anadys Pharmaceuticals, Inc.

Scriptgen Pharmaceuticals, Inc.

Merck Frosst Canada, Inc.

Yi Bin Xiang

Kelvin T Lam

Vincent Boyd

Robert N Young

Cheuk K Lau

Yves Leblanc

Robert H Murray

Marc Labelle

Claude Dufresne

Sharon T Cload

Nicholas J Sisti

C Richard Wobbe

Jaime E Arenas

Yves Gareau

Peng Wang

Xiaodan Mei

Elizabeth S Fleming

Andrei Caracoti

Daniel Moore

Pamela Mingo

Shuhao Zhu

The present invention provides pharmaceutical formulations comprising 1,3,5-triazine derivatives. The compounds and formulations of the present invention exhibit a range of activities, including antiviral and antibiotic activities, and the formulations may be used, alone or in combination, as a method of treating a patient in need of antiviral and/or antibiotic therapy. The triazine derivatives of the present invention bind to and inhibit functional nucleic acids, and hence, have broad applicability in the treatment of conditions associated with DNA and RNA viruses.

Triazine antiviral compounds

Disclosed are pharmaceutical compositions comprising aryl and heteroaryl hydrazone, hydrazine and thiosemicarbazone derivatives of formulae I and II, and methods for using the compositions as antifungal agents. The invention also relates to novel aryl and heteroaryl hydrazone, hydrazine and thiosemicarbazone derivatives of formulae I and II, their preparation, to pharmaceutical compositions containing them, and to methods of using them to alleviate fungal infections.

Hydrazone, hydrazine and thiosemicarbazone derivatives as antifungal agents

Disclosed are pharmaceutical compositions and formulations comprising benzoquinoline derivatives having the formula (I) to (V), wherein formula (I) is:

Benzoquinoline derivatives useful as antibacterial agents

Disclosed are pharmaceutical compositions and formulations comprising the compound:

Aryldiamine derivatives useful as antibacterial agents

Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists

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Acton, MA, United States of America

Yi Bin Xiang