Tel Hashomer Medical Research Infrastructure and Services Ltd.

Nikken Sohonsha Corporation

Epitech Mag Ltd.

Everads Therapy Ltd.

Tel Hashomer Medical Research Infrastructure and Services Ltd., the Chaim Sheba Medical Center

Accutome, Inc.

Ygal Rotenstreich

Mordecai Rosner

Ifat Sher-Rosenthal

Dror Harats

Michael Belkin

Tomer Carmeli

Aviv Shaish

Itzik Ronen

Ifat Sher

David Daily

Hagay Drori

Gad Lewkonya

Lior Raday

Mordechai Rosner

Provided is a device for injection into an interlayer of an organ of a subject. The device includes a needle having a size transitional portion terminating in a sharp needle distal tip. The device also includes an elongated tissue separator that is shiftable in the needle lumen. An actuator shifts the tissue separator in the needle lumen between a first position, in which the separator distal tip is fixedly positioned proximally to the needle distal tip, and a second position in which the separator distal tip is fixedly positioned a predetermined distance distally from the needle distal tip.

Device for injecting a substance into an interlayer of a body tissue or organ

The invention provides a method of noninvasively treating a condition associated with reduced integrity or increased permeability of an epithelial layer by a series of magnetic pulses having a magnitude of up to 3 T, wherein the magnetic pulses are designed to induce an electric field having a magnitude of up to 250 Volt per meter adjacent to a target treatment area, the condition particularly being ocular condition associated with reduced barrier function of the cornea. The invention provides a device for effecting the tissue treatment, creating series of pulses exhibiting a rate of change of more than 200 T/s in the absolute value.

Enhancing epithelial integrity by a sequence of magnetic pulses

The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.

Method for delivery of compositions to the eye

A system and method for determining a state of health of an eye using a pupillometer is provided comprising an ocular fixture, a testing compartment, a camera, and a controller. The testing compartment comprises a plurality of chromatic beam emitters arranged about a visual field. The ocular fixture is positioned to facilitate exposure of light sensitive ocular structures of the eye to a chromatic stimuli. The camera is positioned to record temporal pupil responses of the eye. The controller controls emission wavelength, intensity, and duration of the chromatic beam emitters. The controller processes temporal pupil response data to generate signals representative of the eye positioned at the ocular fixture in response to the chromatic stimuli at a plurality of locations in the visual field. The method comprises driving the chromatic beam emitters with the controller to generate signals using chromatic stimuli and determining the state of health of the eye.

System and method for performing objective perimetry and diagnosis of patients with retinitis pigmentosa and other ocular diseases

Disclosed are methods of subretinal delivery of therapeutic compositions to the eye of a mammal. Also disclosed are devices useful for the subretinal delivery of therapeutic compositions to the eye of a mammal.

Subretinal delivery of therapeutic compositions

A pupillometer system includes a computer, a camera, and a testing compartment provided in the form of a substantially hemispheric bowl, where the substantially hemispheric bowl includes a plurality of chromatic beam emitters arranged about a visual field forming a plurality of visual field testing points. The plurality of chromatic beam emitters generate a first chromatic stimulus that stimulates a first anatomical structure of an eye and a second chromatic stimulus that stimulates a second anatomical structure of the eye where the first anatomical structure is different than the second anatomical structure. The camera records a pupil response of one or more eyes. The computer generates quantitative pupillary light reflex (PLR) measurements of the PLR in response to the stimuli, determines at least one PLR response ratio, and determines a state of health of the one or more eyes utilizing the at least one PLR response ratio.

System and method for objective chromatic perimetry analysis using pupillometer

In one embodiment, a portable pupillometer including a testing compartment, at least one ocular disposed on the testing compartment, two or more light sources disposed in the testing compartment and forming a plurality of visual stimuli for a subject looking through the at least one ocular, at least one camera configured to capture images of a pupil of the subject via infrared detection, the images indicating pupillary responses to the two or more light sources, and an interface for connection with a computing device external to the pupillometer, the interface adapted to (i) provide, to the computing device, images from the at least one camera, and (ii) receive, from the computing device, control signals for controlling the plurality of light sources.

Pupillometers and systems and methods for using a pupillometer

The present invention provides a device and a method for non-invasively enhancing the integrity of the cornea by applying a magnetic field, thereby treating eye disorders.

Device and method for reducing the permeability of the cornea

The present invention relates to a system, device and a method for objective visual field testing and in particular, to such a system and method in which provides objective chromatic perimetry test or color vision test using a pupillometer.

Provided is a method for improving day photopic vision and/or cone-derived visual field and visual function in a subject suffering from a retinal disease or trauma including administering to the subject a pharmaceutically effective amount of crudepowder. Also provided is a method for improving night vision and/or rod derived visual field in a subject suffering from a retinal disease including administering to the subject a pharmaceutically effective amount of crudepowder. A pharmaceutical composition for improving day vision and/or visual field in a subject suffering from a retinal disease including crudepowder is also provided.

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Kfar Bilu, Israel

Ygal Rotenstreich