Nanjing Sanhome Pharmaceutical Co., Ltd.

Yexin Liao

Hai Feng Wang

Yong Wang

Hai Jun Wang

Yazhou Wang

Chao Li

Qi Liu

Liwen Zhao

Chen Wang

Hongyan Chen

Xu Quan

Guochuang Zheng

Chunhuan Jiang

Shengwei Yang

Menghua Chen

Hai Wang

Disclosed are a class of compounds which are inhibitors of acetyl-CoA carboxylase (ACC) and the use thereof. In particular, provided are compounds as shown in formula I or isomers, pharmaceutically acceptable salts, solvates, crystals or prodrugs thereof, and methods for preparing the same, and pharmaceutical compositions comprising the compounds and the use of the compounds or compositions for treating and/or preventing diseases associated with ACC expression, such as fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases. The compound has a good inhibitory activity against ACC and shows good promise to be a therapeutic drug for fibrotic diseases, metabolic diseases, cancers or tissue hyperplasia diseases. 

Compound as ACC inhibitor and use thereof

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Jiangsu, China

Yexin Liao