Dingfu Biotarget Co., Ltd.

Yeqiong Fei

Ting Xu

Xiaoxiao Wang

Jianjian Peng

Yan Luan

Shilong Fu

Hui Ma

Meng Zhao

Xiaolong Pan

Shuli Ma

Shanshan Ning

Disclosed are a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof. a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof.

Fully human antibody against human CD 137

The present application provides an anti-OX40 human antibody. In particular, a human antibody specifically binding to OX40 is obtained with yeast display screening, and the affinity of the antibody is improved with affinity maturation. The present application also provides a use of the antibody for the prevention or treatment of tumors.

Anti-OX40 antibody and application thereof

Growing community of inventors

Jiangsu, China

Yeqiong Fei