Chung Ang University Industry Academic Cooperation

Chungbuk National University Industry-Academic Cooperation Foundation

Industry Academic Cooperation Foundation Hallym University

Yeoun Sook Chun

Jae Chan Kim

Sung Wook Wee

Kyoung Woo Kim

Soo Hyun Park

Kwang Sic Joo

Kyong Mi Min

Kyu Wan Kim

Doo Hwan Oh

Soo Ik Chang

Young Joo Shin

The present invention provides a pharmaceutical composition for the prevention or treatment of glaucoma, wherein the pharmaceutical composition includes angiogenin or a fragment thereof as an active ingredient. Angiogenin or a fragment thereof according to the present invention activates aqueous humor outflow due to NO generation increase, Schlemm's canal expansion, and intercellular interval widening, thereby reducing intraocular pressure. Accordingly, angiogenin and a fragment may be useful for the prevention and treatment of glaucoma.

Angiogenin for treatment of glaucoma

Provided is a pharmaceutical composition for treating corneal endothelium wounds, the composition including angiogenin as an effective ingredient. The present invention relates to a new topical therapeutic use of angiogenin for treatment of corneal endothelium wounds, wherein the angiogenin that is generally known to be involved in angiogenesis activates a PI3K/Akt/eNOS pathway thereof in ocular corneal endothelium to increase migration and proliferation of corneal endothelial cells that are not capable of self-proliferation and to promote prevention and treatment of corneal endothelial cell wounds.

Pharmaceutical composition for treatment of corneal endothelial wounds containing angiogenin

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Seoul, South Korea

Yeoun Sook Chun