Kaohsiung Medical University

Yeong-Shiau Pu

Chun-Nan Lin

Shyh-Chyun Yang

A-Mei Huang

Tzyh-Chyuan Hour

Jan-Gowth Chang

Bai-Luh Wei

Shen-Jeu Won

Huang-Yao Tu

Kai-Wei Lin

Kim-Hong Gan

Several ursolic acid derivatives and pharmaceutical compositions thereof are provided. The ursolic acid derivatives and the pharmaceutical compositions thereof have at least one of an anticancer and an anti-inflammatory effects. A method for increasing a reactive oxygen species in a cell is also provided. The method comprises a step of providing the cell with a pharmaceutical composition including an ursolic acid derivative.

Ursolic acid derivative and pharmaceutical composition thereof

The present invention is correlated with a derivative of 18&#x3b2;-glycyrrhetinic acid apt to suppressing cancer cells, which is selected from a group comprising of structure I and structure II: wherein residue Ris selected from one of CHand CHCH, residue Ris selected from one of COOCH, COOCHCH, COOCH(CH), CONHCHCH, CONHCHCHCH, and CONHCH(CH), and residue Ris selected from one of COOCHCH, COOCH(CH), CONHCHCH, CONHCHCHCH, and CONHCH(CH).

Derivative of 18&#x3b2;-glycyrrhetinic acid apt to suppress cancer cells

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Kaohsiung, Taiwan

Yeong-Shiau Pu