Konkuk University Glocal Industry-academic Collaboration Foundation

Am Sciences Inc

Hlb Science Inc.

Yeong Min Park

In Duk Jung

Sung Jae Shin

Jung Hee Park

Seung Jun Lee

Seung-Hyun Lee

Doo Hyun Kim

Yong Taik Lim

Yangmee Kim

Kyun Hwan Kim

Tae Heung Kang

Byoung Yul Soh

Yong Joo Kim

Seung Pyo Choi

Yong Ho Park

Jae-Yong Park

Kun Ho Lee

Mi Suk Lee

Soo Jung Shin

Minho Moon

Sujin Kim

Sung Min Kim

Wahn Soo Choi

Hee Jo Park

The present invention provides: a peptide having antibacterial activity; a composition for preventing or treating sepsis comprising same; and an antibacterial composition. More specifically, the peptide according to the present invention has the excellent effects of not only suppressing the growth of bacteria but removing endotoxins derived from bacteria, thus exhibiting an excellent therapeutic effect on sepsis, and thus can be usefully used to prevent or treat sepsis. In addition, the peptide according to the present invention has selectively excellent antibacterial activity against Gram positive/negative bacteria, and thus can be usefully used in an antibacterial composition for Gram-positive/negative bacteria, or to prevent or treat various infectious diseases caused by Gram-positive/negative bacteria. Furthermore, the peptide according to the present invention exhibits excellent resistance against proteolytic enzymes, and is highly stable, and thus is expected to be utilized in various forms, such as a pharmaceutical composition, a cosmetic composition, a food composition, a health food composition, a feed composition, and a quasi-drug composition.

Polypeptide having antibacterial activity, composition for preventing or treating sepsis comprising same, and antibacterial composition

The present invention relates to a pharmaceutical composition for treating or preventing hepatitis B, comprising: at least one oligonucleotide selected from the group consisting an oligonucleotide represented by a nucleic acid sequence of SEQ ID NO: 1, 2, or 6 or a nucleic acid sequence complementary thereto; and an oligonucleotide having at least one chemical modification on the oligonucleotide, as an active ingredient, and a method for screening a therapeutic agent for hepatitis B according to the formation of a G-quadruplex by HBV and a candidate material. The pharmaceutical composition forms a G-quadruplex with HBV and reduces cccDNA (covalently closed circular DNA) and thus can be used in the treatment or prevention of hepatitis B.

Pharmaceutical composition for preventing or treating hepatitis B

Provided is an antibacterial composition against carbapenem-resistant gram-negative bacteria which includes, as an active ingredient, adenylate kinase (ADK) protein derived from. The ADK protein derived from, according to the subject matter, has excellent antimicrobial activity against carbapenem-resistant gram-negative bacteria, and thus may be usefully used in a variety of fields as an antibacterial composition.

Antibacterial composition for combating carbapenem-resistant gram-negative bacteria comprising ADK protein as active ingredient

The present invention relates to a composition for preventing or treating sepsis or septic shock including a-derived adenosine kinase (ADK) protein as an active ingredient. The-derived ADK protein according to one exemplary embodiment of the present invention has an effect of inhibit binding between the LPS and cells by binding to LPS, and also has an excellent therapeutic effect against sepsis by enhancing viability in a sepsis animal model and suppressing inflammatory response in the lung and cell death in the spleen.

Compositions for preventing or treating sepsis or septic shock compromising ADK protein as active ingredient

The present invention relates to an antibacterial composition containing, as an active ingredient, adenylate kinase or adenosine kinase (ADK) protein derived from, and a composition for preventing or treating infectious diseases. In addition, the present invention relates to a composition for preventing or treating sepsis or septic shock. Furthermore, the present invention relates to a method for preventing, improving or treating an infectious disease comprising administering the present antibacterial composition. The ADK protein derived fromaccording to the present invention has excellent antibacterial activity selectively against gram-negative bacteria, and thus can be favorably used as an antibacterial composition against gram-negative bacteria or for the prevention or treatment of infectious diseases caused by gram-negative bacteria. In addition, the ADK protein has an excellent sepsis treatment effects, thus can be favorably used for the prevention or treatment of sepsis or septic shock.

Antibacterial composition containing ADK protein as active ingredient, or composition for preventing or treating sepsis

Growing community of inventors

Seoul, South Korea

Yeong Min Park