Korea Institute of Ocean Science & Technology

Samsung Medison Co., Ltd.

Samsung Electronics Co., Ltd.

Yeon Ju Lee

Jong Seok Lee

Duhgoon Lee

Ji Hoon Lee

Hyi Seung Lee

Hee Jae Shin

Sol Park

Dae Hwan Kim

Sang Hyeon Yoon

Hwa Sun Lee

Byeoung Kyu Choi

Bo Hyun Mun

Dan Bi Sung

Chan Hong Park

Gi Tae Lee

Disclosed are a method for synthesizing a thieno[3,2-b]pyridine-5(4H)-one derivative by using a gold catalyst and a use of the derivative compound, wherein the novel thieno[3,2-b]pyridine-5(4H)-one derivative of the present disclosure, which is a compound synthesized using gold as a catalyst, has fluorescence characteristics with a wide range of emission wavelengths and thus can be helpfully used in various industrial fields, such as physics, chemistry, and biomedicine research.

Method for synthesizing thieno[3,2-b]pyridine-5(4H)-one derivative compound, using gold catalyst, and use therefor

The present invention relates to new compounds derived from marine actinomycetes, and the new compound according to the present invention has an inhibitory effect of NO production on BV-2 microglia stimulated with LPS, and thus can be utilized for the prevention and treatment of neuroinflammatory diseases.

Compounds derived fromand uses thereof

The present invention relates to a novel thieno[3,2-b]pyridine-5(4H)-one derivative compound, a preparation method thereof, and a use thereof. The novel thieno[3,2-b]pyridine-5(4H)-one derivative compound according to the present invention is synthesized via an aza-[3+3] cyclization addition reaction using BOP, wherein the compound is obtained by synthesizing a 4-arylthiophen-3-amine in which aryl groups such as 4-piperidyl-C6H4, 4-pyrrolidyl-C6H4, 4-MeOC6H4, 3,4,5-(MeO)3C6H4, C6H5, 4-C6H5C6H4, and 4-F3COC6H4 are introduced via a synthesis process by a bromination reaction, a hydrolysis reaction, a decarboxylation reaction, and a Suzuki coupling reaction of methyl 3-aminothiophene carboxylate, and by synthesizing 4-arylthiophen-3-amine and mono-methyl fumarate via a formal aza-[3+3] cyclization addition reaction using BOP and conjugation. Accordingly, novel thieno[3,2-b]pyridine-5(4H)-one derivative compounds according to the present invention have fluorescence properties with a wide range of emission wavelengths and thus may be utilized in various industrial fields such as physics, chemistry, and biomedical research.

Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof

Disclosed are a novel rhamnolipid compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof in the present disclosure. The novel rhamnolipid compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof selectively exhibits cytotoxicity to human cancer cell lines, thereby inhibiting the growth of cancer cells, and thus has particularly excellent preventive or therapeutic effects against the above-mentioned types of cancers.

Rhamnolipid compounds and use thereof

Provided are an ultrasound diagnosis apparatus and method of controlling the same. The ultrasound diagnosis apparatus includes: a probe configured to acquire ultrasound image data with respect to an object by transmitting ultrasound signals to the object; a processor configured to obtain an ultrasound image based on the ultrasound image data, transmit the ultrasound image and a time stamp indicating a time point when the ultrasound image is obtained in real-time to a client apparatus, and store, in a memory, obtained ultrasound still cuts at respective first time intervals, together with the time stamp; and a communicator configured to receive a request for a still cut including a first time stamp from the client apparatus, wherein the processor is further configured to transmit to the client apparatus an ultrasound still cut corresponding to the first time stamp from among the stored obtained ultrasound still cuts.

Ultrasound diagnosis apparatus and method of controlling the same

Growing community of inventors

Gyeonggi-do, South Korea

Yeon Ju Lee