Korea Institute of Science and Technology

Hedgehog, Inc.

Yeon Gyu Yu

In Geol Choi

Sang Taek Jung

Key-Sun Kim

Ye Sun Han

Youn Jae Kim

Jae Ryeon Ryu

Jae Hwan Lim

Jung-Hyun Na

Sung-Hou Kim

Byoung Joon Ko

Won Kyu Lee

Sung Hou Kim

Hye-Mi Ahn

Bong-Suk Jin

Jae-Ryeon Ryu

Man-Seok Ju

The present invention relates to a monoclonal antibody or a fragment thereof that recognizes and binds specifically to the extracellular domain of endothelin receptor type A as an antigen. The monoclonal antibody of the present invention is suitable for use in a therapeutic agent for hypertension or cancer associated with endothelin receptor type A.

Endothelin receptor type a activity regulating antibody

The present invention relates to peptides that can inhibit the infection of HIV, and more particularly, to peptides consisting of less than 30 amino acids which can introduce a helix capping motif into a peptide derived from C-terminal helical region (its 628-646 amino acid region) of gp41, an envelope glycoprotein of HIV, as well as consisting of the symmetrical bivalent peptide through the introduction of a branched amino acid, Fmoc-Lys(Fmoc)-OH at C-terminus of its peptide, and induce a more stable helical structure thus inhibiting the infection of HIV.

Peptides for inhibition of HIV infection

The present invention relates to a method for detecting a substance having an activity to inhibit HIV infection rapidly, economically and safely. The present invention uses the characteristics that if a function of transmembrane protein gp41 of HIV is inhibited, HIV infection is also inhibited, and therefore the function of gp41 depends on the interaction between two helical structures of gp41. The method of the present invention is to detect a substance to inhibit HIV infection by an immunoassay using the interaction between the variant protein Trx-N, which is prepared by binding the N-terminal helical domain of gp41 to Trx (thioredoxin) and the variant protein GST-C, which is prepared by binding the C-terminal helical domain of gp41 with GST-C (Glutathione S-transferase). This immunoassay can be used for automatic detection of the substance to inhibit the activity of gp41 can be carried out by the method. As a result, it is possible to investigate HIV infection-inhibiting activity of a number of previously known compounds or natural compounds, and it can attribute to the development of therapeutic agent of HIV infection.

Method for detecting a substance having an activity to inhibit HIV infection using immunoassay and variant protein used for said method

Gene sequences of superoxide dismutase of Aquifex pyrophilus which is one of hyperthermophile microorganism and protein expressed therefrom are provided, wherein the protein is used as a necessary medicament in treatment of inflammation, disease of autoimmunization, chromosome lesion and the like, and particularly, A. pyrophilus is a hyperthermophile which can grow at the optimum temperature of 85.degree. C., and thus the superoxide dismutase of A. pyrophilus has a higher thermal stability than other organisms, resulting in further broad applications in the pharmaceutical field.

Gene sequence of Aquifex pyrophilus superoxide dismutase and protein

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Seoul, South Korea

Yeon Gyu Yu