Sk Chemicals Co., Ltd.

Yeo-Jin Park

Joon-Gyo Oh

Jae-Sun Kim

Bong-Yong Lee

Won-No Youn

Won-Jae Choi

Yong Youn Hwang

Jong-Seob Im

Yong-Youn Hwang

Soo Min Lee

Won Jae Choi

Hun-Taek Kim

Hunseung Yoo

Hun-Teak Kim

Namho Kim

Wonno Youn

Hye-Min Kim

JongSeob Im

Joon-gyo Oh

Hae-In Rhee

Jong-su Yoo

Wonjae Choi

Sung-Hyuk Kim

Young-me Lee

The present invention relates to a patch comprising a high content of rivastigmine per unit area, which can be continuously administered for a long time. The rivastigmine patch according to the present invention is capable of continuous release of rivastigmine for a long period of time, preferably 3 days, more preferably 4 days or more after attachment, and has excellent physical and chemical stability.

Rivastigmine patch for long-term administration

A method for preparing a transdermal absorption composition includes mixing rotigotine and an antioxidant at a weight ratio of 1:0.0001 to 0.1. A transdermal therapeutic system includes a substrate and a drug-containing adhesive layer disposed on the substrate and including an antioxidant at a weight ratio of 1:0.0001 to 0.1. The method and system of the present invention suppress the crystallization of rotigotine as well as the generation of related substances, thereby increasing the long-term storage stability of a therapeutic product containing rotigotine or related substances.

Rotigotine-containing transdermal absorption preparation with improved stability

Provided is a transdermal delivery system (for example, in the form of a patch) having a double-layer structure including a drug-containing matrix layer and an adhesive layer, wherein the drug-containing matrix layer is obtained by completely dissolving donepezil using a certain polymer and then formulating along with an adhesive; and a process for preparing the same. The transdermal delivery system according to the present invention does not show any crystallization of donepezil in the formulation, can release donepezil at a uniform rate for a long time, and can inhibit the release dumping phenomenon that occurs in a transdermal delivery system having a single-layer structure.

Percutaneous absorption preparation containing donepezil, and method for preparing same

The present invention relates to a rivastigmine-containing patch having improved storage stability and proper release property.

Patch containing rivastigmine

A transdermal composition comprising tolterodine having improved storage stability is disclosed. The transdermal composition comprising tolterodine contains an antioxidant to stabilize tolterodine and can be stored for a long period of time.

Transdermal composition comprising tolterodine

Disclosed is a composition for transdermal administration containing tolterodine. The composition comprises lidocaine or a pharmaceutically acceptable salt thereof to achieve enhanced skin penetration. The composition enhances the skin penetration of tolterodine. Therefore, a successful commercial application of a tolterodine-containing transdermal preparation based on the composition can be expected.

Composition with improved skin penetration for transdermal delivery of tolterodine

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Seoul, South Korea

Yeo-Jin Park