Council of Scientific and Industrial Research

Yennu Sangiah Sadanandam

Jhillu Singh Yadav

Alla Venkata Rao

Meera Manjaya Shetty

Imtiaz Ahm Ansari

A process for the preparation of (+) (2S, 3S)-3-(2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-propionic acid which comprises treating the (.+-.) compound of (2RS, 3RS) 3-(2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-propionic acid (formula (II)) with the (+) compound of the 2-methylbenzylamine (formula (III)) and an alkali in the presence of a polar solvent, the amount of the compound of the formula (III) and the alkali being in half equivalent amount of compound of the formula (II) employed, separating the precipitate (+) amine salt form of (2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-propionic acid from the 1(-) salt form remaining in solution, by known methods treating the (+) amine salt from with an organic solvent and then decomposing the (+) amine salt form to produce (+)(2s, 3s)-3-(2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-propionic acid.

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Secunderabad, India

Yennu Sangiah Sadanandam