Gendaq Limited

Plasticell Limited

The Rockefeller University

Medical Research Council

Sangamo Biosciences, Inc.

The Rockfeller University

Gendaq Limited, C/o Brobeck Hale and Dorr

Progenitor Labs Limited

Yen Choo

Aaron Klug

Mark Isalan

Christopher Graeme Ullman

Marina Tarunina

Michael Moore

Isidro Sanchez-Garcia

Nam-Hai Chua

Christopher James Johnson

Mylvaganam Jeyakumar

Juan Pablo Sanchez

John Girdlestone

Martin Arthur Town

Diana Hernandez-Jaramillo

Isidro Sanchez Garcia

Xiaohai Liu

Sachin Dinesh Patel

Diana Hernandez

Suwan Nalin Jayasinghe

Lilian Hook

Fraser Hornby

Lindsey Reynolds

Simon Lister

Christophe Demaison

Robert Merrifield

Cedric Humbert

Shahzad Ali

Thomas Watson

Aaron Tsu Tshen Chuang

Dennis Saw

Shhankar Balasubramanian

Meritxell Rosell

Isidro Sánchez-Gárcia

Patrick Klaus Odenwälder

Patrick Klaus Odenwalder

Marina Trunina

Jeyakumar Mylvaganam

Meritxell Roseell

A hydrogel capsule comprising a stem cell core that has been induced to differentiate into a hematopoietic lineage cell, and methods for the production of hematopoietic lineage cells from stem cells encapsulated in a hydrogel.

Methods for producing cells of the hematopoietic lineage using hydrogel encapsulation

The present invention relates to brown adipose tissue (BAT) cells derived from adult stern or progenitor cells, derived from adult white fat tissue (WAT), as well as to methods for deriving such cells.

Deriving brown adipose tissue cells

One embodiment of the invention provides a method of processing cell culture data. The data comprises results from a large number of samples, the results being obtained by performing multiple stages of cell culture in succession on each sample. Each stage represents a cell culture treatment having a particular set of conditions, such that each sample follows a protocol specified by the identity and order of the treatments applied to the cell culture. The method includes specifying a subset of the samples that yielded a desired cell culture outcome. The method further includes performing a computer-implemented analysis of the results from the samples in the subset to produce an ordering or grouping for the results. The ordering or grouping helps to identify one or more protocols that are effective for obtaining the desired cell culture outcome. The analysis for producing the ordering or grouping utilizes information on similarities between different protocols.

Apparatus and method for processing cell culture data

A method for determining the effect of a plurality of culture conditions on a cell, comprising the steps of: a) providing a first set of groups of cell units each comprising one or more cells, and exposing said groups to desired culture conditions; (b) pooling two or more of said groups to form at least one second pool; (c) subdividing the second pool to create a further set of groups of cell units; (d) exposing said further groups to desired culture conditions; (e) optionally, repeating steps (b)-(d) iteratively as required; and (f) optionally assessing the effect on a given cell unit of the culture conditions to which it has been exposed.

Cell culture

Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.

Binding proteins for recognition of DNA

Relating to binding proteins for recognition of DNA

The present invention provides an apparatus for culturing cells which may comprise two or more culture compartments and a pooling compartment, wherein each of said two or more culture compartments may be separated from the other culture compartments; each of said two or more culture compartments which may comprise a port for the addition or removal of medium; and the pooling compartment communicates with said two or more culture compartments. The present invention also relates to a stand for apparatus for culturing cells.

Vessel for culturing cells

The invention relates to a zinc finger polypeptide library in which each polypeptide comprises more than one zinc finger which has been at least partially randomized, and to a set of zinc finger polypeptide libraries which encode overlapping zinc finger polypeptides, each polypeptide comprising more than one zinc finger which has been at least partially randomized, and which polypeptide may be assembled after selection to form a multifinger zinc finger polypeptide.

Nucleic acid binding polypeptide library

The invention provides a method for designing a nucleic acid binding protein of the Cys2-His2 zinc finger class capable of binding to a nucleic acid quadruplet in a target nucleic acid sequence, wherein binding to base 4 of the quadruplet by an alpha-helical zinc finger nucleic acid binding motif in the protein is determined as follows: if base 4 in the quadruplet is A, then position +6 in the alpha-helix is Glu, Asn or Val; if base 4 in the quadruplet is C, then position +6 in the alpha-helix is Ser, Thr, Val, Ala, Glu or Asn; if base 4 of the quadruplet is G, the position +6 in the alpha helix is Arg or Lys; if position 4 in the quadruplet is T, then position +6 in the alpha helix is Ser, Thr, Val or Lys.

Nucleic acid binding proteins

Culture vessel

The present invention relates in one aspect to a method for determining the cell culture history of a cell unit labelled with more than one type of tag comprising the steps of: (a) measuring one or more parameters of each tag that is used to label the cell unit; (b) identifying each tag in the cell unit; and (c) correlating the identity of each tag to the identity of the cell unit and/or the specific cell culture conditions to which the cell unit has been exposed.

Method for determining the cell culture history of a cell unit labeled with more than one type of tag

Disclosed herein are methods and compositions for modulating HIV infection by regulating expression of one or more receptors.

Modulation of HIV infection

Growing community of inventors

London, United Kingdom

Yen Choo