H.t. Chemicals, Inc.

Modcol Corporation

Other

Yehuda Shalon

Tadmor Shalon

Ilya B Nykin

Danny D Meyer

Danny Meyer

Y Andrew Li

Charles W Martin

A chromatographic device in which a chromatographic column pivots on a compression cylinder. Prior to pivoting, one end of the column is sealed with an end cap, the column is at least partially filled with a chromatographic medium and a piston is frictionally engaged within the column. The chromatographic column is then pivoted onto the compression cylinder, and the compression device is operated to push the piston into the column with a telescoping rod. The telescoping rod is then retracted, leaving the piston in place. The chromatographic column is then removed from the compression cylinder. A spring assembly is then inserted into column above the piston, and held in place with a torque mechanism mounted on the chromatographic column. The torque mechanism includes a bolt that can be tightened to provide a variable spring pressure against the piston. A rotating coupling is provided so that the chromatographic column and compression column can be operated in at least two different directions to facilitate the removal of the medium from the chromatographic column after use.

Method and apparatus for packing and sealing chromatographic columns

A chromatographic device comprising a column body having a first end and a closed second end. The device further includes a piston inside the column body, a chromatographic medium, a rod, and a locking mechanism. The chromatographic medium is within the column body and between the piston and the second end. The rod has a longitudinal rod axis and is operatively engageable with the piston for pressing the piston in the column body. The locking mechanism is adapted for locking the rod relative to the column body in a manner to prevent movement of the rod relative to the column body in an outward longitudinal direction away from the piston without preventing movement of the rod relative to the column body in an inward longitudinal direction toward the piston. Preferably, the chromatographic device includes a spring for exerting a constant axial compression against the piston to prevent the formation of voids in the packing medium.

Chromatographic device with piston locking mechanism and method of

Apparatus that maintains compression in a tube

Method for packing and sealing chromatographic columns

A slurry compressor for obtaining a homogeneous, pressurized, packed absorbent bed of slurry in a chromatographic column is provided. The compressor includes a solid first portion and a second portion which is a slightly tapering walled structure integral with the first portion. An annular groove is disposed within the first portion and a resilient O-ring sealing member is disposed within the ring. A split ring backup-spacer element can also be positioned within said groove to provide increased sealing to prevent leakage of the particles beyond the compressor element. An adapter element for enabling the insertion of the compressor into the column without damaging the surface of the O-ring is also disclosed. A handled straight adapter is also provided to enable the column to be supporting during packing and to be stabilized during column disassembly. A method of packing a column which includes shaking the slurry-filled column prior to pressurizing the column is set forth.

Slurry compressor, apparatus for guiding compresser, and method for

A liquid chromatography column that can be rapidly packed without a reservoir column is disclosed. The column includes a double sealed compressor piston with a mixture delivery bore extending through the body of the piston. Resilient sealing means are provided in annular grooves provided in the piston. The piston retains a frit and slurry scraper is mounted to the piston. A method of packing such a column is also disclosed. An outlet end plate including solvent drainage bores is provided. A threaded end cap including radial slots in an inner surface for a threaded column is disclosed, as is an adaptor for joining flanged and threaded columns.

Column slurry packing compressor

In chromatography columns, a pair of end plates mounting upon integral column flanges provided at either end of said chromatography column, each end plate mounting a series of frits and O-rings in place within cylindrical grooves provided within each end of the column, each end plate arranged contiguously with the enclosed frits incorporating a series of radially disposed grooves, to provide for dissemination of the incoming chemicals uniformly about the entire cross-section of the column chamber, to provide for efficient dispersion of said chemicals throughout the entire slurry packing contained therein, and incorporating equivalent grooves upon the inner surface of the end plate connecting with the outlet end of the column, to assure uniformity of collection of the chromatography treated chemicals as they are discharged to a location for usage or collection.

Zero void column end plate for chromatography

Zero-void column end plate for chromatography

This invention relates to high pressure liquid chromatography and to chromatographic columns employed therein. These columns may be modularly modified as to length and/or internal diameter and may contain other components in the modular system, for example, column sections, adapters and cone adapters, for joining column sections of different internal diameters, and end plate units for funnelling in or discharging out fluids; said end caps or lids, with or without funnel shaped means, for facilitating the liquid entrance or exit; and porous frits, with or without handles, all used in conjunction with the column sections to facilitate their usage for performance of specific chromatographic functions. The column sections have terminal flange-like means for accommodating the joining together for formations of a system suitable for high pressure liquid chromatography of the preparative or semi-preparative type.

High pressure liquid chromatography columns

A slurry compressor for obtaining a homogeneous absorbent bed in a chromatographic column wherein said compressor includes a shaped member having external dimensions slightly less than the internal dimensions of the column in which the bed of particles is being compressed. The compressor having an innermost portion and an outermost portion, integrally connected, the innermost portion being a solid segment incorporating a lower surface, while the outermost portion includes a hollowed interior forming a walled structure extending integrally from the solid segment, with the walled structure flaring slightly outwardly to assure a reasonably snug contact with the inner surface and interior wall of the associated column.

Growing community of inventors

St. Louis, MO, United States of America

Yehuda Shalon