Magnetecs Corporation

Pharmaco-kinesis Corporation

Cognos Therapeutics Inc.

Autonomous Medical Devices Inc.

Sensor Kinesis Corporation

Other

Magnetics, Inc.

Johnson; David

Luboff, Paladin

Wu, Winston

Zimmerman, Kyle

Jordan, Brett

Chan, Herwin

Thomas, Marlon

Farkas, Leslie

Yehoshua Shachar

Thomas C Chen

Leslie Farkas

Laszlo Farkas

Bruce Marx

David Johnson

Winston Wu

Eli Gang

Chad Srisathapat

Thomas Jay Lobl

Virote Indravudh

Brett LeBeau Jordan

Allan R Schwartz

Juan Ramon Gonzalez

Kyle Zimmerman

Christian Merot

Herwin Chan

Jeffrey A Brydle

Roger D Kornberg

Paladin Luboff

Steven J Kim

Marlon S Thomas

Martin Ellenbogen

Shawn Hakim

Thomas Chen

Brett Jordan

Lazlo Farkas

Marlon Thomas

A method of administering bortezomib into a brain tumor by a pump implanted in a brain of a subject. The method includes administering a drug to a tumor in a central nervous system of a subject, the method comprising, delivering a therapeutically effective amount of the drug into a brain, tumor by a pump implanted in a brain of the subject, wherein administration of the drag to the subject in the central nervous system is contraindicated because of toxicity of the drug.

Intratumoral delivery of bortezomib

The illustrated embodiments of the invention include an MRI compatible apparatus having: a refillable drug reservoir; a hermetically sealed, implantable chamber; a pump disposed in and hermetically sealed within the hermetically sealed, implantable chamber and fluidically communicated to the drug reservoir; and control electronics disposed in and hermetically sealed within the hermetically sealed, implantable chamber and electrically communicated to the pump. The refillable drug reservoir, hermetically sealed, implantable chamber, pump and control electronics are MRI compatible.

Method and apparatus for a long-term, fully implantable MRI compatible drug pump

A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).

Skull-mounted drug and pressure sensor

The illustrated embodiments include a method of operating a SAW sensor to detect a sample in a fluid which includes the steps of: providing a SAW sensor with a functionalized detection lane in a handheld, portable assay device and sensor system; maintaining the functionalized detection lane of the SAW sensor dry until the sample is fluidically disposed in the detection lane; fluidically disposing the sample in the functionalized detection lane; removing fluid the functionalized detection lane to concentrate the sample in the functionalized detection lane to increase the probability of a specific antibody-antigen interaction; washing the functionalized detection lane so that substantially only the specific antigen-antibody interaction remains in the functionalized detection lane; removing fluid from the functionalized detection lane again; and measuring concentration of the sample while the functionalized detection lane is fluid-free.

Detection of cardiac troponin or biological markers via shear horizontal surface acoustic wave biosensor using a wet-dry bioanalytical technique

An apparatus for performing cerebral micro-dialysis to treat neurological disease of a patient's brain includes a catheter for implantation in or near the patient's brain, an implantable pump communicated with the catheter to transport cerebrospinal fluid (CSF) from the patient, which CSF contains diseased cells or biomolecules associated with the neurological disease, and an implantable separation device communicated with the pump wherein the diseased cells or biomolecules are removed, where the separation apparatus includes a dialysis membrane impregnated with an antibody, a reversible electrostatic filter, and/or a magnetic field effect fractionation chamber wherein a magnetically-tagged antibody scavenges and aids in the removal of circulating diseased cells or biomolecules from the CSF.

Apparatus and method for cerebral microdialysis to treat neurological disease, including Alzheimer's, Parkinson's or multiple sclerosis

A surface acoustic wave (SAW) performs a rapid, label-free detection of biological species. Biosensing and detection of multiple analytes multiplexed by an array of sensing lanes is configured to enable bio-amplification using engineered DNA encoded libraries as the probe through a phage display procedure to enhance specificity, capture statistics for the detection, screening and analyzing of the analyte in vitro. A biochemical formulation minimizes the limit of detection (LOD) at a threshold magnitude on the order of a femtomolar concentration. Additional enhancement of the apparatus is achieved by use of an analog front end to amplify biochemical events.

Surface acoustic wave biosensor employing an analog front end and DNA encoded libraries to improved limit of detection (LOD) with exemplary apparatus of the same

A system and method for performing a portable, fast, field assay of a small sample biological analyte includes a microfluidic cartridge and a reader with which the microfluidic cartridge is selectively communicated. A closed microfluidic circuit mixes and recirculates the analyte with a buffer. A shear horizontal surface acoustic wave (SAW) detector communicates with the microfluidic circuit and has a plurality of channels including at least one functionalized sensing channel in which the mixed analyte and buffer is recirculated and sensed. Capture of the analyte is amplified by recirculation of the analyte and buffer, and detection is amplified by use of an all-purpose endospore display mass amplification.

Field portable, handheld, recirculating surface acoustic wave and method for operating the same

An apparatus for autonomous cleaning of an electrical line includes: an inductive pick up coil concentrically disposed around the electrical line which pick up coil derives its power from the electrical line through inductive coupling; a drive motor having a driving wheel in contact with the electrical line; a power conditioning circuit for conditioning the inductively picked up power from the pick up coil, the drive motor being coupled to the power conditioning circuit; at least one rotating brush in contact with the electrical line for cleaning the electrical line; at least one brush motor coupled to the at least one brush to rotate the brush, the brush motor being coupled to the power conditioning circuit; and a control circuit for controlling the operation of the drive motor and brush motor, the control circuit coupled to the power conditioning circuit.

Apparatus and method for cleaning high power transmission lines

A system and method is described for a catheter guidance system which allows an operator to use a mapping catheter to specify tissue target locations for the automatic guidance of a second therapeutic catheter. The operator places a mapping catheter at a desired location, and commands the catheter guidance system by either selecting a point on that catheter or one of the catheter electrode electrocardiograms. The operator may target the selected dynamic location, or tissue contact beyond that location on a specific side of the mapping catheter.

System and method for targeting catheter electrodes

A system for a mapping and ablation catheter. The catheter includes a MOSFET sensor array that provides better fidelity of the signal measurements as well as data collection and reduces the error generated by spatial distribution of the isotropic and anisotropic wave fronts and error associated with near and far field's signal averages. The system maps the change in bioelectric potential in the vicinity of an activation wave front. During measurement, the manifold carrying the sensor array translates and rotates so as to achieve a measure of high potential employing an impedance value. The system of guiding and controlling the movement of the catheter distal end is able to deliver energy for ablating the renal artery nerve and thereby providing a safe and efficient method and apparatus for neuromodulation.

Method and apparatus for magnetically guided catheter for renal denervation employing MOSFET sensor array

An aptamer-based solid-state electrochemical biosensor for label-free detection ofserovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between theouter membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any presentbacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.

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Growing community of inventors

Santa Monica, CA, United States of America

Yehoshua Shachar