Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Fulcrum Sp Ltd.

Yehonathan Pouny

Oded Shoseyov

Amnon Wolf

Ira Marton

Arie Altman

Or Dgany

Tal Alegrand

Wangxia Wang

Dan Pelah

SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.

Sp1 polypeptides, modified Sp1 polypeptides and uses thereof

Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids encoding SPs; antibodies recognizing SPs; the use of SPs for stabilizing, refolding, repairing, preventing aggregation and de-aggregating macromolecules such as proteins; fusion proteins including SPs; nucleic acid constructs encoding the fusion proteins; and their uses in a variety of methods and applications.

Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof

Growing community of inventors

Giv′at-Shmuel, Israel

Yehonathan Pouny