University of Pittsburgh

Yee Key Li

David L Steed

Yoram Vodovotz

Qi Mi

Gary An

Patricia A Hebda

Ivan Petrov Yotov

Gilles Clermont

Joshua Thomas Sullivan

Katherine Verdolini Abbott

Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.

Modeling wound healing

Growing community of inventors

Pittsburgh, PA, United States of America

Yee Key Li