Bionumerik Pharmaceuticals, Inc.

Ye Wu

Harry Kochat

Jianyan Wang

Qiuli Huang

Xinghai Chen

Kesavaram Narkunan

Vincent Gerusz

The invention claimed herein relates to an improvement in a process for synthesizing a compound of formula Ib: 

Process for synthesizing 6-quinazolinyl-ethyl-benzoyl and related antifolates

A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with a silylated heterocyclic compound in a modified Minisci-type alkylation reaction to produce 7-substituted derivatives of camptothecin.

Process for making camptothecin derivatives

A process for synthesizing substantially enantiomerically pure L-amino acids, particularly L-&#x3b3;-methylene glutamic acid, and esters and salts thereof. The process includes the derivatization of (2S)-pyroglutamic acid, and the decyclization of the resulting derivative to form the desired end product.

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Helotes, TX, United States of America

Ye Wu