Novavax, Inc.

Basf Corporation

Basf Catalysts LLC

Honda Motor Co., Ltd.

Ye Liu

Gale Smith

Michael J Massare

Pascaline Tran

Michael P Galligan

Xinsheng Liu

Peter M Pushko

Yingyun Wu

Jing-Hui Tian

Bin Zhou

Gregory M Glenn

Sarathi Boddapati

Erica Shane

Keshavaraja Alive

Cynthia Oliver

Young Gin Kim

Qinglin Zhang

David Flyer

Xinzhu Liu

Milena Kudziela

Ahmad Moini

Robert J Farrauto

Hiroyuki Horimura

Gerald Stephen Koermer

Xiaolin Yang

Christopher R Castellano

Gregory J Glenn

Wenyong Lin

Shau-Lin Frank Chen

Gale E Smith

John R Adomaitis

Qingyuan Hu

Doan Lieu

Akiko Iwasa

Louis Fries

Iksung Cho

Michelle Casper

Weiliang Feng

Danielle Maria Shacklady-McAtee

Pascaline Harrison Tran

Xin Zhu Liu

H Pascaline Tran

P Michael Galligan

Gin Young Kim

Alive Keshavaraja

The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.

Modified RSV F proteins and methods of their use

Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Vaccine compositions having improved stability and immunogenicity

Disclosed herein are methods and nanoparticles suitable for use in reducing exacerbations in COPD patients. The methods and compositions advantageously reduce the incidence of hospitalization in COPD patients that occurs in response to environmental insults such as exposure to or infection by RSV. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

Methods and compositions for treating respiratory disease

Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towardsinfection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.

Methods and compositions for inducing immune responses against

The invention provides a catalyst article including a substrate underlying a multi-layer catalyst composition and a multi-layer catalyst composition comprising a first layer and a second layer, the first layer positioned between the substrate and the second layer, wherein the first layer comprises a first porous refractory oxide material impregnated with at least one base metal component and the second layer comprises a second porous refractory oxide material impregnated with at least one platinum group metal. Either the second porous refractory oxide material is a porous refractory oxide material other than alumina or the catalyst composition further comprises an intermediate layer between the first layer and the second layer, the intermediate layer comprising a refractory oxide material other than alumina. Methods of making and using the catalyst article are also provided, as well as emission treatment systems comprising the catalyst article.

Multi-layer catalyst composition for internal combustion engines

Methods and compositions for inducing immune responses against Clostridium difficile

Catalytic articles comprising a substrate having a catalytic coating thereon, the catalytic coating comprising a catalytic layer having a thickness and an inner surface proximate to the substrate and an outer surface distal to the substrate; where the catalytic layer comprises a noble metal component on support particles and where the concentration of the noble metal component towards the outer surface is greater than the concentration towards the inner surface are highly effective towards treating exhaust gas streams of internal combustion engines. The articles are prepared via a method comprising providing a first mixture comprising micron-scaled support particles and applying the first mixture to a substrate to form a micro-particle layer; providing a second mixture comprising nano-scaled support particles and a noble metal component having an initial pH and applying the second mixture to the micro-particle layer and calcining the substrate.

Catalytic articles

Catalyst articles comprising palladium and related methods of preparation and use are disclosed. Disclosed is a catalyst article comprising a first catalytic layer formed on a substrate, wherein the first catalytic layer comprises palladium impregnated on a ceria-free oxygen storage component and platinum impregnated on a refractory metal oxide, and a second catalytic layer formed on the first catalytic layer comprising platinum impregnated on an oxygen storage component and rhodium impregnated on a zirconia-coated or yttria-coated alumina. The palladium component of the catalyst article is present in a higher proportion relative to the other platinum group metal components. The catalyst articles provide improved reductions in NOx in exhaust gases, particularly after lean-rich aging.

Aging-resistant catalyst article for internal combustion engines

Disclosed herein are nanoparticles containing MERS virus proteins in polymer structures, and compositions containing the nanoparticles formulated for administration as immunogenic compositions. Also provided herein are vector constructs encoding the proteins, and host cells containing the vector constructs. The disclosure also includes methods of making the nanoparticles and administering them to vertebrates, including methods of inducing immune responses to MERS that reduce or prevent infection by the virus.

Immunogenic middle east respiratory syndrome coronavirus (MERS-CoV) compositions and methods

Growing community of inventors

Clarksville, MD, United States of America

Ye Liu