Wisconsin Alumni Research Foundation

Ye Jin Eun

Douglas Benjamin Weibel

Katherine Ann Hurley

Marie Hazel Foss

Maoquan Zhou

Described herein are antimicrobial compounds identified via a high-throughput inhibitor screen of the in vitro activity of MipZ, which is an ATPase that regulates division site placement in. The compounds and their analogs are active against bacterial membranes and thus represent a novel class of antimicrobial compounds. The antimicrobial compounds are effective against both actively growing bacterial cells as well as bacterial cells in the stationary phase. The antimicrobial compounds are also effective against bacteria in biofilms.

Antimicrobial compounds, compositions and methods of use thereof

Described herein is a novel class of inhibitors of bacterial cell division. Several lines of evidence suggest the compounds disclosed herein specifically target the division process and have antibacterial activity in vitro and in vivo. The inhibitors are useful for treating subject in need of treatment for bacterial infections as will as for inhibiting bacterial growth, such as growth on contaminated surfaces.

Growing community of inventors

Cambridge, MA, United States of America

Ye Jin Eun