Corning Incorporated

Ye Fang

Ann MeeJin Ferrie

Brian L Webb

Joydeep Lahiri

Yulong Hong

John Christopher Mauro

Anthony Glenn Frutos

Fang Lai

Po Ki Yuen

Norman Henry Fontaine

Elizabeth Tran

Qiang Fu

David Henry

Yue Zhou

Vasiliy Nikolaevich Goral

Huayun Deng

Corinne Walerack

Laurent A G Picard

Qi Wu

Martial Hervy

Peter J Kalal

Steven J Jonas

David H Randle

Aize Li

Lina Ma

Valerie Claudine Lacarriere

Jinlin Peng

Srikanth Raghavan

Alexander Mikhailovich Efremov

Sadashiva K Pai

Jin Su Kim

John Stephen Peanasky

Allison Jean Tanner

Eric John Mozdy

Stephen Joseph Caracci

Ying Wei

Alain R E Carre

Wei Sun

Michael S Pambianchi

Michael Joshua Snyder

Paul Ernest Gagnon, Jr

Florence Verrier

Lingyan Wang

Hongming Wang

Jeffrey Glenn Lynn

Oberon Denaci Deichmann

Haiyan Sun

Terry T Goodrich

Alain Re Carre

Wei Wang

Chuan-Che Wang

Yan Jin

Y Alice Gao

Dana Lynne Widmer-Quiel

Jun Xi

Haibei Hu

Yu A Gao

A cell culture apparatus may include a substrate defining a well. The well may define an interior surface, an exterior surface, an upper aperture and a nadir. The substrate may define a thickness between the interior and exterior surfaces that has a thickness proximate the nadir that is greater than or equal to a thickness proximate the upper aperture.

Microwell design and fabrication for generation of cell culture aggregates

A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.

Proteinase-free coatings for colony passaging

A method for manufacturing a microfluidic device () includes depositing a bonding layer () on a surface of a second glass layer () of a glass substrate having a first glass layer () and the second glass layer () fused to the first glass layer (), such that a masked region of the surface is covered by the bonding layer, and an exposed region of the surface is uncovered by the bonding layer; removing a portion of the second glass layer corresponding to the exposed region of the surface to form a flow channel () in the glass substrate; and bonding a cover () to the glass substrate with the bonding layer ().

Microfluidic devices and methods for manufacturing microfluidic devices

Magnetic microcarrier beads have a particle size of 1 to 1000 micrometers and include a composite core and a polymer coating that surrounds and encapsulates the core. The composite core includes magnetic particles embedded within an indigestible polymer matrix. The coating is a digestible or indigestible polymer that facilitates cell adhesion to the surface of the beads during cell culture. Magnetic force can be used to agitate the microcarrier beads during cell culture as well as to separate the beads from cultured cells or processed bio-media.

Magnetic microcarriers

A dental formulation including: a bioactive glass composition as defined herein, in an effective amount; and a suitable carrier as defined herein, in an effective amount. Also disclosed is a method of making and using the dental formulation to treat, for example, dentin sensitivities.

Bioactive glass compositions and dentin hypersensitivity remediation

An aluminoborate composition, an alumino-borosilicate glass composition, or a mixture thereof, and solid or hollow microspheres thereof, as defined herein. Also disclosed are methods of making and using the disclosed compositions, for example, forming microspheres for use in bioactive applications, and composition extracts for use in treating or healing wounds.

Bioactive glass microspheres

A borophosphate glass composition including BO, PO, and CaO, and optionally a source additive selected from: LiO, NaO, KO, AlO, ZnO, MgO, FeO/FeO, CuO/CuO, and mixtures thereof, as defined herein. Also disclosed are bioactive compositions or substrates including the disclosed borophosphate glass composition, and at least one live cell. Also disclosed are methods of inhibiting or increasing the relative amount of species containing boron, phosphorous, or both, being released into an aqueous solution from aborophosphate glass composition defined herein. Also disclosed is a method of proliferating cells on a bioactive substrate as defined herein. Also disclosed are related glass compositions that exclude one of BO, PO, and CaO.

Bioactive borophosphate glasses

An aluminoborate glass composition, including BO, AlO, PO, NaO, and CaO, as defined herein. Also disclosed are bioactive compositions including the disclosed aluminoborate glass composition, a suitable fluid, and at least one live cell. Also disclosed is method of limiting the amount of boron released into an aqueous solution from a disclosed aluminoborate-containing glass composition as defined herein. Also disclosed is a method of proliferating cells on a bioactive substrate as defined herein.

Bioactive aluminoborate glasses

A label-free resonant waveguide grating biosensor imager system for measuring beat patterns and dynamic mass redistribution (DMR) signals of cultured cardiomyocytes in the absence and presence of a drug molecule. The disclosure also provides a method using the imager system for analyzing the beat patterns and the DMR signals of the cardiomyocytes to assess drug-induced cardiotoxicity.

Label free method for assessing chemical cardiotoxicity

Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in high throughput methods and can be multiplexed.

Label free biosensors and cells

A method for hit compound identification in a high throughput, label-free biosensor cellular assay, one method including, for example:

High-throughput high-information content label-free cell biology screening methods

A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type.

Dual-target biosensor cell assays

The disclosure provides a system and method for characterizing a single live-cell response to a stimulus with a biosensor imaging system having cells immobilized on the biosensor at a resolution level of a single cell, as defined herein.

Single-cell label-free assay

Growing community of inventors

Painted Post, NY, United States of America

Ye Fang