Transtech Pharma, Inc.

Ye Edward Tian

Adnan M M Mjalli

Robert Rothlein

Jeffrey C Webster

Robert Carl Andrews

Govindan Subramanian

Jeff Jiqun Zhu

Bapu Reddy Gaddam

Samuel F Victory

Eric Joel Benjamin

Ghassan Qabaja

Murty N Arimilli

John Dankwardt

Adnan MM Mjalli

Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin C2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.

Rage fusion proteins and methods of use

Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin C2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.

Nucleic acid molecules encoding rage fusion proteins

RAGE fusion proteins, formulations, and methods of use thereof

Rage fusion proteins

The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.

Substituted heteroaryl derivatives, compositions, and methods of use

Growing community of inventors

Jamestown, NC, United States of America

Ye Edward Tian