Pulse Medical Imaging Technology (shanghai) Co., Ltd

Yazhu Chen

Bing Liu

Shengxian Tu

Miao Chu

Bo Xu

A method for computing fractional flow reserve (FFR), including receiving geometrical parameters of a blood vessel segment including a proximal end and a distal end, the geometrical parameters including a first geometrical parameter, a second geometrical parameter and a third geometrical parameter; and with the proximal end as a reference point, deriving a reference lumen diameter function and a geometrical parameter difference function based on the geometrical parameters and the distance from the position along the segment of blood vessel to the reference point. Derivatives of the geometrical parameter difference function are calculated in multiple scales. FFR is computed as a ratio of a second blood flow pressure at the first location of the blood vessel to a first blood flow pressure at the proximal end of the segment based on the multiple scales of derivative difference functions and the maximum mean blood flow velocity.

Method and system for calculating blood vessel pressure difference and fractional flow reserve

A system for estimating post-virtual stenting fractional flow reserve (FFR) capable of: receiving geometrical parameters of a blood vessel segment, the geometrical parameters comprising first, second and third geometrical parameters; with a proximal end as a reference point, deriving a reference lumen diameter function and calculating a pre-virtual stenting percent diameter stenosis based on the above geometrical parameters and the distance from position along the segment to the reference point; receiving a virtual stenting location; calculating a geometrical parameter of a virtual lumen of the post virtually-stented segment, deriving a post-virtual stenting geometrical parameter difference function and calculating a percent diameter stenosis based on the third geometrical parameter, the virtual stenting location and the reference lumen diameter function; taking derivative difference functions of the post-virtual stenting geometrical parameter difference function in multiple scales; and obtaining FFR based on the multiple scales of derivative difference functions and a maximum post-virtual stenting mean blood flow velocity. Post-virtual stenting FFR is estimated based on changes in percent diameter stenosis and the maximum mean blood flow velocity after virtual stent implantation using a multi-scale calculation method.

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Shanghai, China

Yazhu Chen