Calcimedica, Inc.

Migenix, Inc.

Lion Bioscience Ag

Pfizer Corporation

Smithkline Beecham Corporation

Mitokor, Inc.

Yazhong Pei

Jeffrey Paul Whitten

Jianguo Cao

Evan W Rogers

Zhijun Wang

Jonathan Bryant Grey

Brian Dyck

Soumitra S Ghosh

Kenneth Stauderman

Gonul Velicelebi

Walter H Moos

Robert E Davis

Christen M Anderson

Tomas R Szabo

Hengyuan Lang

William Christensen Clevenger

Sandra Eileen Wiley

Scott W Miller

Ronald R Tuttle

Xiao-Qing Tang

Spiros Liras

Beverly E Girten

Jack Roos

Timothy Gahman

Kevin Ross Holme

Michael K Ahlijanian

Sandra R Slivka

Karen J Watson-Straughan

Yuewu Chen

Ian William James

Douglas L Hitchin

Kevin C Dines

Frank King

Kenneth A Stauderman

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

Compounds that modulate intracellular calcium

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.

Described herein are compounds of Formula (I): 

Trisubstituted thiophenes that modulate intracellular calcium

Described herein are compounds of Formula (I): wherein A, J, Z, X, Rand Rare defined herein, and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

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San Diego, CA, United States of America

Yazhong Pei