Medshine Discovery Inc.

Merck Sharp + Dohme Corp.

Yaxian Cai

Jian Li

Shuhui Chen

Charles Z Ding

Guoping Hu

Lihong Hu

Zhaobing Xu

Hailong Yang

Shiqi Han

Hao Wu

Craig Alan Coburn

Kun Liu

Shawn J Stachel

Richard Soll

Thomas G Steele

Xuanjin Peng

Xiaoxiang Du

Provided are a class of KRAS G12C mutein inhibitors, which relate in particular to a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof. 

Pyridone-pyrimidine derivative acting as KRAS G12C mutein inhibitor

Pyridone-pyrimidine derivative acting as KRASG12C mutein inhibitor

The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved. 

Spiropyrrolidine beta-secretase inhibitors for the treatment of alzheimer'S disease

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Waigaoqiao Free Trade Zone, China

Yaxian Cai