Ajinomoto Co., Ltd.

Yasuyuki Otake

Tomoyuki Onishi

Kunisuke Izawa

Masakazu Nakazawa

Naoko Hirose

Takashi Nakano

Daisuke Takahashi

Yutaka Honda

Sachiko Oka

Daigaku Hideura

Herein are disclosed a process for increasing in purity, or purifying, an N-protected-&#x3b2;-aminoalcohol which process comprises (i) adding water to a polar organic solvent in which an N-protected-&#x3b2;-aminoalcohol such as a (2R,3S)- or (2S,3R)-3-tert-butoxycarbonylamino-1-halo-2-hydroxy-4-phenylbutane or the like, or (ii) crystallizing such an N-protected-&#x3b2;-aminoalcohol from a diol or a diol-based mixed solvent, and a process for producing the corresponding N-protected-&#x3b2;-aminoepoxide which process comprises treating, with a base, the thus purity-enhanced N-protected-&#x3b2;-aminoalcohol. Such N-protected-&#x3b2;-aminoalcohols and N-protected-&#x3b2;-aminoepoxides are both useful as synthetic intermediates for medicine compounds, such as, e.g., HIV protease inhibitor and the like.

Processes for preparation of N-protected-&#x3b2;-amino alcohols and N-protected-&#x3b2;-amino epoxides

Production method of &bgr;-amino-&agr;-hydroxycarboxylic acid

Method for producing epoxide crystal

Herein is disclosed a process for producing an &agr;-aminohalomethyl ketone derivative which comprises subjecting to catalytic reduction the corresponding &agr;-aminodihalomethyl ketone derivative, and which process is efficient and suited for industrial production thereof.

Process for producing &agr;-aminohalomethyl ketone derivatives

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Kawasaki, Japan

Yasuyuki Otake