Chugai Seiyaku Kabushiki Kaisha

Yasuyuki Katoh

Takeshi Yokota

Hiroyuki Nagano

Tamotsu Yamazaki

Mitiro Takagi

Novel compounds of the present invention are represented by the general formula (1) ##STR1## wherein R.sub.1 is hydrogen atom or amino, R.sub.2 is fluorine atom or methoxy, R.sub.3 is hydrogen atom or a lower alkyl having 1 to 3 carbon atoms, and n is 0 or 1. The compounds of the general formula (1) exhibit higher antibacterial activity with fewer side-effects than known quinolone antibiotics such as ofloxacin and norfloxacin. Further, the compounds having the general formula (1) have reduced phototoxicity which normally accompanies 6,8-defluoroquinoline antibiotics.

Novel quinolonecarboxylic acid derivatives

A compound of the following general formula or a salt thereof ##STR1## (where R.sub.1 and R.sub.2 which may be the same or different are each an alkyl group having 1 to 3 carbon atoms; R.sub.3 is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.4 and R.sub.5 which may be the same or different are each a hydrogen atom or an alkyl group having 1 to 8 carbon atoms; m and n which may be the same or different are each an integer of 1 to 7; provided that R.sub.4 and R.sub.5 are not a hydrogen atom at the same time), and a process of preparing the same are disclosed. The compound is useful in the treatment of arrythmias because it exhibits desirably strong effects for treating arrythmias and minimum undesirable side effects.

Growing community of inventors

Shizuoka, Japan

Yasuyuki Katoh