Shionogi Company Limited

Purdue Pharma L.p.

Yasuyoshi Iso

Yukio Tada

Kohji Hanasaki

Laykea Tafesse

Jianming Yu

Xiaoming Zhou

Bin Shao

Noriyuki Kurose

Kouki Fuchino

Naoko Yamaguchi

The invention relates to compounds of Formula I: wherein Ar, Ar, Ar, L, L, Y, Z and v are defined in the specification, and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof.

Heterocyclic compounds

It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein Ris a group represented by the formula: &#x2014;Y&#x2014;Y&#x2014;Y&#x2014;Rwherein Yis single bond or the like; Yis &#x2014;C(&#x2550;O)&#x2014;NH&#x2014; or the like; Yis optionally substituted aryl or the like; Ris hydrogen or the like; Ris alkyl or the like; Ris alkyl or the like; Ris optionally substituted alkyl or the like; or Rand Rtaken together with the adjacent atom form cyclic group or the like.

Pyridone derivatives having a binding activity to the cannabinoid type 2 receptor

It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I):&#x2003;wherein Ris a group represented by the formula: &#x2014;Y&#x2014;Y&#x2014;Y&#x2014;Rwherein Yis single bond or the like; Yis &#x2014;C(&#x2550;O)&#x2014;NH&#x2014; or the like; Yis optionally substituted aryl or the like; Ris hydrogen or the like; Ris alkyl or the like; Ris alkyl or the like; Ris optionally substituted alkyl or the like; or Rand Rtaken together with the adjacent atom form cyclic group or the like.

Pyridone derivatives having affinity for cannabinoid 2-type receptor

Growing community of inventors

Osaka, Japan

Yasuyoshi Iso