Jnc Corporation

Sofsera Corporation

Yasuto Umeda

Yuichi Yamamoto

Yoshihiro Matsumoto

Masami Todokoro

Shigeyuki Aoyama

Yasuo Matsumoto

Takafumi Takebayashi

Yuka Yamamoto

Masami Shiina

Shinichi Takasaki

Takahiro Kawai

Akihiro Uchida

An adsorbent, which can be produced by a method in which a particle size, a pore size, a specific surface area or the like can be easily controlled, and is suitable for isolation of biomolecules. The adsorbent contains aggregates of calcium phosphate-based particles, and has an average pore size of 15 to 36 nanometers and a specific surface area of 40 to 90 m/mL when measurement is carried out by mercury porosimetry.

Adsorbent and method for producing the same

A method for preparing a chromatography medium having the properties of high virus adsorption and high fluidity, and a method for producing a virus vaccine using the chromatography medium are provided. The chromatography medium is obtained by forming a sulfated polysaccharide bound with porous particles having an exclusion limit molecular weight of 6000 Da or less when pure water is used as mobile phase and standard polyethylene glycol is used and an average particle size in the range of 30-200 &#x3bc;m.

Preparation method of chromatography medium

The present invention provides a porous cellulose gel having a high mechanical strength capable of being operated at a higher flow rate, and a method for producing the same. To a suspension liquid of cellulose particles, a crosslinking agent in an amount of from 4 to 12 times the amount of the cellulose monomer in terms of moles and an alkali in an amount of from 0.1 to 1.5 times the amount of the crosslinking agent in terms of moles are added continuously dropwise or added dividedly over a prescribed period of time, whereby flow rate characteristics of a resulting porous cellulose gel can be enhanced. According to the invention, the production efficiency of a polymer substance, such as a nucleic acid and a protein can be enhanced.

Porous cellulose gel, method for producing the same, and use thereof

A Chromatography medium having the properties of high virus adsorption and high fluidity, and a method for producing a virus vaccine using these are provided. The Chromatography medium is formed by binding a sulfated polysaccharide to porous particles having an exclusion limit molecular weight of 6000 Da or less when pure water is used as mobile phase and standard polyethylene glycol is used and an average particle size in the range of 30-200 &#x3bc;m.

Chromatography medium, preparation method of the same, and method for producing virus vaccine using the chromatography medium

A platelet aggregation inducing substance containing as an active ingredient a polypeptide having a peptide fragment represented by formula (1) (component A):-(Pro-X-Gly)-&#x2003;&#x2003;(1)wherein X represents Pro or Hyp; and n represents an integer of from 20 to 5,000.

Platelet aggregation inducing substance

The present invention provides a chromatography packing material having improved flow rate characteristics and adsorption characteristics. In particular, the present invention provides a chromatography packing material suitable for separation and purification of immunoglobulin in the manufacture of antibody preparations. A porous cellulose gel, which is made by adding polysaccharides having a limiting viscosity of 0.21 to 0.90 dL/g to porous cellulose particles, the dry weight per unit volume of the porous cellulose gel being 1.06 to 1.40 times the dry weight per unit volume of the porous cellulose particles, is used. By adding a predetermined amount of polysaccharides having a predetermined limiting viscosity to porous cellulose particles, flow rate characteristics and adsorption characteristics can be improved.

Growing community of inventors

Kumamoto, Japan

Yasuto Umeda