Sanraku-ocean Co., Ltd.

Sanraku Incorporated

Yasutaka Shimauchi

Tomoyuki Ishikura

Takeo Yoshioka

Yasuo Fukagawa

Hamao Umezawa

Tomio Takeuchi

Kageaki Kouno

Kazuhiko Okamura

Yasushi Okumura

Joseph Lein

Kenichi Yamamoto

Shoji Hirata

Toshikazu Oki

Rokuro Okamoto

Tsutomu Sawa

Hiroshi Tanaka

Miharu Maeda

Yasuyuki Kato

Kaoru Yamada

Novel tylosin derivatives are represented by formula: ##STR1## wherein R represents a hydrogen atom, an acetyl group or a propionyl group; X represents a group --CO-- or --SO.sub.2 --; Y represents a fluorine atom, an acetyl group, a methanesulfonyl group, a methylthio group, a benzoyl group or a methoxy group bound to the benzyl group at the 2-position or 4-position; and Z represents a hydrogen atom or a D-mycinose residue: ##STR2## The tylosin derivatives which are antibiotics of macrolide type provide improved antibacterial activity and improved ability of absorption and excretion in vivo.

Tylosin derivatives

A compound represented by the following formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group, R.sub.2 represents a group of the formula --CH.sub.2 NO.sub.2, --CN.fwdarw.O or ##STR2## in which A represents a group of the formula ##STR3## in which R.sub.4 represents a hydrogen atom or an alkoxycarbonyl group, R.sub.5 represents a phenyl, alkoxycarbonyl or alkanoyloxymethyl group, R.sub.6 represents an alkyl group and R.sub.7 represents a phenyl, naphthyl, pyridyl, furyl or thienyl group; and R.sub.3 represents a hydrogen atom or a substituted or unsubstituted hydrocarbon group, and a process for production thereof.

.beta.-Lactam derivatives and process for production thereof

Disclosed are novel anthracyclinone glycosides represented by the chemical formula ##STR1## wherein R.sup.1 is hydrogen or methyl;

Anthracyclinone trisaccharide compounds

A novel antibiotic substance of the formula ##STR1## wherein R.sub.1 is CH.sub.3 and R.sub.2 is --CH.sub.2 --CH.sub.2 -- or R.sub.1 is H and R.sub.2 is --CH.dbd.CH--; and R.sub.3 represents hydrogen, lower alkyl or triphenylmethyl, and including the salts of the compound of formula (I) wherein R.sub.3 is hydrogen, said antibiotic substance having strong antibiotic activity and .beta.-lactamase inhibiting effect, and a method for producing the same by aerobic cultivation of Streptomyces A271.

Antibiotics and derivatives thereof having .beta.-lactamase inhibitory

Novel antibiotic .beta.-lactam compounds, i.e. 7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives of the following formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group or a hydroxyl group,

Antibiotic .beta.-lactam compounds, production thereof, and their use as

A novel antibiotic substance and derivatives thereof, having strong antibiotic activity and .beta.-lactamase inhibiting effect and a method for producing the same by aerobic cultivation of Streptomyces A 271.

Antibiotic PS-5 and derivatives having .beta.-lactamase inhibitory

Growing community of inventors

Ninomiya, Japan

Yasutaka Shimauchi