Daiichi Sankyo Company, Limited

Yasusi Ueda

Nobuyuki Suzuki

Hitoshi Ohki

Masahiro Ikeda

Yoshihiro Shibata

Masahiro Ota

Shinji Matuura

Tooru Okayama

Toshiyuki Nakanishi

Yuichi Aki

Daisuke Fukatsu

Mizuka Yokoyama

It is an object of the present invention to provide a medicament for preventing or treating hyperphosphatemia. The solution is crystals, or hydrate thereof, of a salt of a compound represented by formula (I).

Salt of dicarboxylic acid compound

To provide a crystal of a tricyclic pyrazolopyrimidine compound inhibiting the effect of HSP90. The present invention provides a crystal of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide which inhibits the ATPase activity of HSP90 and which has antitumor activity, a medicament comprising the same, an anticancer agent comprising the same, and the like.

Crystal of a free tricyclic pyrazolopyrimidine derivative

A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1). 

Tricyclic pyrazolopyrimidine derivatives

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Tokyo, Japan

Yasusi Ueda