Chugai Seiyaku Kabushiki Kaisha

Yasushi Yoshimura

Yasuo Koishihara

Masayuki Tsuchiya

Toshihiko Ohtomo

Masaaki Kosaka

Koichiro Ono

Koichiro Chugai Seiyaku Kabushiki Kaisha Ono

Yasuo Chugai Seiyaku Kabushiki Kaisha Koishihara

Toshihiko Chugai Seiyaku Kabushiki Kaisha Ohtomo

The invention provides a reshaped human anti-HM 1.24 antibody having: (A) an L chain having (1) the C region of a human L chain, and (2) the V region of an L chain having the FR of a human L chain and the CDR of the L chain of a mouse anti-HM 1.24 monoclonal antibody; and (B) an H chain having (1) the C region of a human H chain, and (2) the V region of an H chain having the FR of a human H chain and the CDR of the H chain of a mouse anti-HM 1.24 monoclonal antibody. This reshaped human antibody is derived from human antibody and the CDR has a low antigenicity, and the reshaped human antibody of the present invention has a low antigenicity and can be used for medical treatment.

Reshaped human anti-HM 1.24 antibody

A therapeutic agent for lymphatic tumors (excluding myeloma) comprising as an active ingredient an antibody that specifically binds to a protein having the amino acid sequence as set forth in SEQ ID NO:1 and SEQ ID NO:5 and that has a cytotoxic activity.

Remedies for lymphocytic tumors

Growing community of inventors

Gotenba, Japan

Yasushi Yoshimura