Kyoto University

Takeda Pharmaceutical Company Limited

National Cancer Center Japan

Yasushi Uemura

Shin Kaneko

Kyoko Fukuda

Norihiro Ueda

Tetsuya Nakatsura

Atsutaka Minagawa

Yoshiaki Kassai

Toshiaki Yoshikawa

Atsushi Matsuda

An object of the present invention is induction of CD4-positive T cells from pluripotent stem cells. This object is achieved by production of CD4-positive T cells by introducing a CD4 gene or a gene product thereof into T cells induced from pluripotent stem cells.

Method for producing CD4-positive T cells from pluripotent stem cells

Provided is a T cell receptor capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 27 or a complex of the peptide and HLA-A24. A T cell receptor capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 28 or a complex of the peptide and HLA-A02. Disclosed T cell receptors are useful in treating or avoiding cancers which are associated with expression of glypican-3.

T-cell receptor

A method of producing helper T cells, comprising:

Method for producing helper T cells from pluripotent stem cells

Growing community of inventors

Kashiwa, Japan

Yasushi Uemura