Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo K.k.

Yasushi Shida

Makoto Morimoto

Masaji Kasai

Tadashi Ashizawa

Katsushige Gomi

Ikuo Matsukuma

Yukiteru Mimura

Hiroyuki Ishida

Tsutomu Akama

Shiro Akinaga

Hiromitsu Saito

Shun-ichi Ikeda

Kimihisa Ueno

Tokuyuki Kuroda

Toru Sugaya

Yutaka Osawa

Uichiro Kimura

5-Aminoflavone derivatives represented by the formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and represent hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, halogen-substituted or unsubstituted lower alkanoyl or lower alkoxycarbonyl, X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2 are the same or different and represent hydrogen, halogen or lower alkyl, at least one of X.sup.1 and X.sup.2 represents halogen or lower alkyl, X.sup.3 represents hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, halogen, hydroxy, substituted or unsubstituted lower alkoxy, NR.sup.5 R.sup.6 (wherein R.sup.5 and R.sup.6 are the same or different and represent hydrogen, or substituted or unsubstituted lower alkyl, or R.sup.5 and R.sup.6 are taken together to form a heterocyclic group containing the nitrogen atom in the ring), lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, lower alkoxycarbonyl, lower alkanoyl, adizo, cyano, substituted or unsubstituted carbamoyl or lower alkylthiothiocarbonyl: or pharmaceutically acceptable salts thereof.

5-aminoflavone derivatives

Disclosed is pyrazoloacridone derivatives represented by formula (I): ##STR1## wherein: each of R.sup.1a, R.sup.1b, R.sup.1c and R.sup.1d independently represents hydrogen, lower alkyl, --(CH.sub.2).sub.p --X wherein p represents an integer of 1 to 6, and X represents hydroxy, lower alkoxy or --NR.sup.2a R.sup.2b wherein each of R.sup.2a and R.sup.2b independently represents hydrogen, lower alkyl, or --(CH.sub.2).sub.m --Y wherein m represents an integer of 1 to 6, and Y represents hydroxy, lower alkoxy or --NR.sup.3a R.sup.3b wherein each of R.sup.3a and R.sup.3b independently represents hydrogen or lower alkyl

Pyrazoloacridone derivatives

Novel pyrazoloacridone compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have an excellent anti-tumor activity.

6H-pyrazolo-[4,5,1-d,e]acridin-6-one derivatives having anit-tumor

Mitomycin derivatives having potent anti-tumor activity against solid sarcoma 180 tumors and lymphocytic leukemia P-388 tumors.

Mitomycin compounds having useful anti-tumor activity

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Mishima, Japan

Yasushi Shida