Nitto-denko Corporation

Yasushi Sato

Yoshinori Nishiki

Yoshiro Niitsu

Akihiro Kato

Junji Kato

Shigenori Mitsushima

Koji Matsuoka

Akiyoshi Manabe

Setsuro Ogata

Awaludin Zaenal

Shinji Oshima

Kota Miyoshi

An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.

Drug carrier and drug carrier kit for inhibiting fibrosis

Growing community of inventors

Sapporo, Japan

Yasushi Sato