Kyoto University

Kyowa Hakko Bio Co., Ltd.

Hirosaki University

Yasushi Okuno

Tasuku Honjo

Kazuki Nakamura

Gozoh Tsujimoto

Fumihiko Matsuda

Kei Taneishi

Sidonia Fagarasan

Kenji Chamoto

Koichi Murashita

Ryosuke Kojima

Eiichiro Uchino

Shigeyuki Nakaji

Ken Itoh

The present invention provides markers for judging the efficacy of therapy with a PD-1 signal inhibitor before or at an early stage of the therapy. As biomarkers for predicting or judging the efficacy of therapy with a PD-1 signal inhibitor, surrogate indicators of metabolic changes relating to mitochondrial activity in T cells and/or T cell activation in a subject are used. As such indicators, intestinal flora-related metabolites in the serum or plasma, energy metabolism-related metabolites in the serum or plasma, amino acid metabolism-related metabolites and/or derivatives thereof in the serum of plasma, oxygen consumption rate and/or ATP turnover in peripheral blood CD8cells, amino acids in T cells, and T-bet in peripheral blood CD8cells may be used.

Efficacy determination markers in disease treatment by PD-1 signal inhibitor

A data processing method for an estimation of compound-protein interaction using both chemical substance information, such as a chemical property of the compound, and biological information, such as sequence information of genes to rationally and efficiently screen compounds. First space representing space coordinates of a first chemical substance group and second space representing space coordinates of a second chemical substance group are defined, and the first chemical substance group is characterized by a first characteristic amount and the second chemical substance group is characterized by a second characteristic amount, and map transformation of the coordinates of the first space and the coordinates of the second space results in the solution so as to increase the correlation between the first space and the second space using a multivariable analysis technique or a machine learning method.

Estimation of protein-compound interaction and rational design of compound library based on chemical genomic information

Growing community of inventors

Kyoto, Japan

Yasushi Okuno