Tanabe Seiyaku Company, Limited

Yasushi Okazaki

Taku Nagao

Hiromichi Nakajima

Nobuo Ito

Muneyoshi Ikezaki

Masao Hoshiyama

A compound having the formula: ##STR1## wherein Ring A is monohydroxyphenyl, or a pharmaceutically acceptable acid addition salt thereof is prepared by catalytic hydrogenation of a compound having the formula: ##STR2## wherein A' is monobenzyloxyphenyl, and Y is carbonyl or hydroxymethylene. The compound (I) in which Ring A is 4-hydroxyphenyl or 3-hydroxyphenyl is useful as a cardiotonic agent. On the other hand, the compound (I) in which Ring A is 2-hydroxyphenyl is useful as an anti-diabetic agent.

Novel benzylalcohol derivatives as antidiabetics and cardiotonics

Benzylalcohol amine derivatives

A compound of the formula: ##SPC1## Wherein Ring A' is dibenzyloxyphenyl and Y is carbonyl or hydroxymethylene, is subjected to catalytic hydrogenation. A compound of the formula: ##SPC2## Wherein Ring A is dihydroxyphenyl, is produced. The product is useful as a cardiotonic agent. It is also characterized by the high potency ratio of adrenergic .beta..sub.1 -receptor stimulating activity to adrenergic .beta..sub.2 -receptor stimulating activity.

.alpha.-(3,4-Dimethoxyphenethylaminomethyl)-3,4 or

Growing community of inventors

Tokyo, Japan

Yasushi Okazaki