Sumitomo Chemical Company, Limited

Eisai Company, Limited

Sumitomo Rubber Industries Limited

Matsushita Electric Industrial Co., Ltd.

Eisai Inc.

Yasushi Okamoto

Shigeki Hibi

Katsuya Tagami

Isao Yamatsu

Naoki Kobayashi

Akio Imai

Makoto Okita

Takashi Yamanaka

Tetsuya Kawahara

Yuichi Saito

Nobuyuki Yoshida

Masanobu Shinoda

Hiroshi Furukawa

Takeshi Katsumata

Hirotoshi Numata

Toshihiko Kaneko

Takeshi Suzuki

Hiroyuki Yoshimura

Shigeru Souda

Yoshimasa Machida

Seiichiro Nomoto

Seiichi Kobayashi

Mitsuo Nagai

Takashi Sato

Kouichi Kikuchi

Manabu Murakami

Kouichi Katayama

Takayuki Hida

Takashi Inoue

Kiyoshi Oketani

Hiroshi Shirota

Kenichi Chiba

Hideki Ono

Kaname Miyamoto

Ryoichi Hashida

Naoki Tokuhara

Kenji Tai

Masayuki Tanaka

Shujiro Shiga

Hideto Ohhara

Masaki Goto

Hideki Sakurai

Yoshinori Kanno

Yumiko Nagasaka

Shinya Abe

Keisaku Yamamoto

Masatoshi Saito

Ieharu Hishinuma

Junichi Nagakawa

Kazuo Hirota

Tomoaki Seki

Hiromitsu Yokohama

Tsutomu Yoshimura

Yasunori Akita

Koichi Katayama

Takashi Nakata

Tetsuo Uno

Tohru Horie

Koukichi Harada

Osamu Asano

Nobuhisa Watanabe

Tadashi Hikasa

Minoru Yoshinaka

Koichi Abe

Atsushi Inoue

Takao Saeki

Shuji Yoshimi

Tadashi Nagakura

Jun Yagi

Kouziro Matsuo

Masahiro Sakurai

Shiga Shujiro

Eiji Inaba

Tsugio Nishioka

Atsushi Inmaru

Seiji Takaki

Tadashi Higasa

Takashi Satoh

Amidino derivatives represented by the following general formula (I):{where X is a group represented by RSONR&#x2014; (wherein Rrepresents optionally substituted Caryl, etc. and Rrepresents hydrogen atom, etc.), etc., Arrepresents 2,6-naphthylene, etc., Rrepresents hydrogen atom, etc. and Y represents carboxyphenyl, etc.}and their pharmacologically acceptable salts or solvates.

Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them

Carboxylic acid derivatives having fused rings

Fused-ring carboxylic acid derivatives

The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism. A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {wherein the symbol ##STR2## represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: --O-- or --S--, or a group represented by the formula: ##STR3## [wherein R.sup.k (k: 1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R.sup.7 and R.sup.8 being a group represented by the formula: ##STR4## (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.

A benzothiazole derivative or a pharmacologically acceptable salt thereof of the following formula, as defined in the claims, which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective: ##STR1##

Benzothiazole compounds which are substituted by pyridymethyl

Naphthalene derivatives of the formula: ##STR1## wherein R.sup.1, represents a hydrogen atom, a lower alkyl group or an acyl group; R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroaryllakyl group; R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group; R.sup.6 is C.sub.1-6 alkyl; and m is 0 or an integer of from 1 to 2 useful in treating autoimmune diseases are disclosed.

Naphthalene derivative

A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective. A benzothiazole derivative represented by the following general formula (I): ##STR1##

Pyridyl substituted benzothiazole compounds which have useful

A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where X and Y may be the same or different from each other and are each a hydroxyl group, a group represented by the formula --(--OCH.sub.2 --).sub.n --OR.sup.6, wherein n is 0 or 1 and R.sup.6 is a lower alkyl group, or an acyl group.

Quinone derivatives and pharmacological use

The present invention is a quinone derivative which exhibits excellent therapeutic activity represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein A stands for a group represented by the formula: ##STR2## (wherein R.sup.3, R.sup.4 and R.sup.5 is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are each a lower alkoxy group

Quinone derivatives

A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective. A benzothiazole derivative represented by the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.3 are either the same or different and represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a group represented by the formula --(CH.sub.x)--.sub.q wherein q is a integer of from 1 to 4;

A naphthalene derivative having the formula is new and useful for medicine. ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;

A rubber modified styrene based resin composition which is excellent in the balance of impact strength and shapes appearance such as gloss and especially image clarity, and has a wide applicability in the field of housings for household electric apparatuses and the like requiring such a shapes appearance as having been difficult to achieve with conventional rubber modified polystyrenes (HIPSs), and which comprises a styrene based resin forming a matrix and particulate soft component containing rubbery elastomer dispersed in the matrix, wherein the soft component dispersed in the composition consists of a small-sized particulate component having a core/shell structure and an average particle size of 0.1 to 0.4 .mu.m and a large-sized particulate component having a cell structure and an average particle size of 0.8 to 2.0 .mu.m, a ratio by weight of the small-sized component to the large-sized component being in the range of 90:10 to 99:1, and the resin composition contains an amount of 0.01 to 0.5% by weight of methyl phenyl silicone oil.

Rubber modified styrene based resin composition

A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where R1 is selected from the group consisting of alkyl, alkenly, alkynyl or heterocycle, R2 is a substituted nitrogen containing radical wherein the substituents on said nitrogen are selected from the group consisting of hydrogen, substituted or unsubstituted lower alkyl or heterocycles, and where said nitrogen may be a ring heteroatom, and R3, R4 and R5, may be the same or different and each are hydrogen, lower alkyl or lower alkoxy groups.

Ouinone derivatives and pharmacological use

A heat-resistant, high-impact polystyrene composition is disclosed, comprising:

Heat-resistant high-impact polystyrene composition

A naphthalene derivative having the formula is new and useful for medicine. ##STR1## [wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;

Growing community of inventors

Ibaraki, Japan

Yasushi Okamoto