Other

Kyowa Hakko Bio Co., Ltd.

Yasushi Ogasawara

Jacob C Greenberg

Snezna Rogelj

Tetsuro Ujihara

Yasuharu Satoh

Pamela Hall

Tohru Dairi

Charles Melancon

Shohei Hayashi

An object of the present invention is to provide a microorganism that efficiently produces a PUFA and a method for producing a PUFA using the microorganism. The present invention relates to a microorganism capable of producing a polyunsaturated fatty acid (PUFA), in which a gene encoding an exogenous polyketide synthase dehydratase (PS-DH) domain having a higher activity against 3-hydroxyhexanoyl acyl carrier protein (3-hydroxyhexanoyl ACP) than an endogenous FabA-like β-hydroxyacyl-ACP dehydratase (FabA-DH) domain has been introduced into a microorganism having a PUFA metabolic pathway, and the like.

Microorganism producing polyunsaturated fatty acid and method for producing polyunsaturated fatty acid

In one aspect, this disclosure describes a pharmaceutical composition that generally includes frankiamicin A and a pharmaceutically acceptable carrier. In another aspect, this disclosure describes a method of treating a subject having, or at risk of having, a condition caused by a microbial infection treatable with frankiamicin A. Generally, the method includes administering to the subject an amount of frankiamicin A effective to ameliorate at least one symptom or clinical sign of the condition.

Frankiamicin A compositions and methods

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Sapporo, Japan

Yasushi Ogasawara