Shimadzu Corporation

Kyoto University

Yasushi Ishihama

Jun Yanagibayashi

Kenichi Yasunaga

Shinya Imamura

Hiroaki Kozawa

Yuichiro Fujita

Tomoya Niinae

Kazuyoshi Yoshii

Koshi Imami

Yumi Komori

A pump unit includes a pump and a metal ion trap. The pump includes a metal member that comes into contact with a mobile phase. The pump pumps a mobile phase through a flow path. The metal ion trap includes a filter element. The filter element includes a metal ion retention structure for retaining metal ions by interacting with the metal ions included in a mobile phase. The filter element is provided in the flow path for a mobile phase pumped by the pump. The pump unit may be provided in a chromatograph.

Pump unit and chromatograph

In order to appropriately set MSanalysis conditions, an MSanalysis executer () makes a mass spectrometer () perform an MSanalysis (where m is an integer from 2 to n) to acquire three-dimensional data showing an intensity for each of the N m/z values and each of the M retention times (where N and M are natural numbers). Based on the three-dimensional data, a data matrix creator () creates data matrix X in which intensity data are arranged in N rows which differ from each other in m/z value and M columns which differ from each other in retention-time value. A matrix factorization executer () determines an N×K spectrum matrix S and K×M profile matrix P (where K is a natural number) by matrix factorization based on data matrix X so that this matrix X is approximated by product SP of the matrices S and P. An m/z detector () detects m/z of a precursor ion originating from a sample component from the values of the matrix elements in each column of matrix S. A retention time detector () detects the retention time of a sample component from the values of the matrix elements in each row of matrix P. Based on the m/z and retention time, an MSanalysis execution condition determiner () determines an execution condition of an MSanalysis including the selection and fragmentation of a precursor ion of a sample component. An MSanalysis executer () makes the mass spectrometer execute an MSanalysis based on the execution condition.

Chromatograph mass spectrometer

Growing community of inventors

Kyoto, Japan

Yasushi Ishihama