Riken Corporation

Sumitomo Chemical Company, Limited

Sumitomo Dainippon Pharma Co., Ltd.

Sumitomo Pharma Co., Ltd.

Racthera Co., Ltd.

Yasushi Hiramine

Yoshiki Sasai

Masayo Takahashi

Atsushi Kuwahara

Suguru Yamasaki

Hitoshi Ban

Futoshi Hasegawa

Masayo Fujiwara

The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3): (1) a first step of culturing pluripotent stem cells in the absence of feeder cells and in a medium containing 1) a TGFβ family signal transduction pathway inhibiting substance and/or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state,(2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and(3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a differentiation-inducing factor to obtain an aggregate containing neural cells or a neural tissue.

Production method for nerve tissue

The present invention provides a method for producing retinal cells or a retinal tissue, comprising the following steps (1)-(3):

Production method for retinal tissue

The present invention provides a compound of formula (1) or a salt thereof wherein ring Qis optionally-substituted Caryl, etc.; Rand Rare independently hydrogen atom, etc.; Wis Calkylene which may be optionally substituted with 1 to 3 fluorine atoms or Ccycloalkyl; Wis &#x2014;NRC(O)&#x2014;, etc. wherein Ris hydrogen atom or Calkyl; ring Qis optionally-substituted Caryl, etc., which has an inhibitory effect on the sphere-forming ability of cancer cells and is useful an agent for removing iPS cells. 

Agent for removing undifferentiated iPS cells

The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3):

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Kobe, Japan

Yasushi Hiramine