Daiichi Seiyaku Co., Ltd.

Yasushi Abiko

Yoshifumi Watanabe

Fumiyoshi Ishikawa

Kinya Kameda

Akira Kosasayama

Shin-etu Ono

Tosaku Miki

Setsuo Kobayashi

Kin-Ya Kameda

Akashi Eriguchi

Yasumasa Yoshie

Kin-ya Kameda

Tsugio Nakazawa

An agent for treatment and prevention of asthma comprising 2-[2-phenyl-2-(2-pyridyl)]ethyl-2-imidazoline or a salt thereof as an active ingredient is disclosed.

Antiasthmatic agent

A compound of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represents a member selected from the group consisting of hydrogen and nicotinoyl, with the proviso that R.sub.1, R.sub.2 and R.sub.3 do not all simultaneously represent hydrogen, and the nontoxic acid addition salts thereof.

Nicotinoyl pantetheine derivatives

A method for treating diabetes comprising administering a therapeutically effective amount of a 2-(2,2-disubstituted)ethylimidazoline of the general formula (I) ##STR1## wherein R is a phenyl group or a 2-pyridyl group or the pharmaceutically acceptable acid addition salts thereof, to a patient having diabetes.

Method for treating diabetes

2-SUBSTITUTED-1,3-DIAZACYCLIC COMPOUNDS OF THE FORMULA: ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sub.2 represents a hydrogen atom, a lower alkoxycarbonyl group, an aliphatic acyl group or an aromatic acyl group, the aromatic ring of which may have one or more substituents selected from a halogen atom, a lower alkyl group, a lower alkoxy group, an acyl group and an acyloxy group; R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group or an aralkyl group; R.sub.4 represents a hydrogen atom, a lower alkyl group or an aryl group; R.sub.6 represents a cyclohexyl group, a pyridyl group or a phenyl group which may have a substituent selected from a halogen atom, a lower alkyl group and a lower alkoxy group; A represents -N.dbd., an -N(lower alkyl)- group or a methylene group; n represents an integer of from 2 to 4, and a dotted line indicates that a double bond is optional; salts of such derivatives; and the method for preparing such compounds and their salts; the compounds and their salts having a distinct anti-diabetic activity in humans and animals.

Treatment of diabetes with 2-substituted-1,3-diazacyclic compounds

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Tokyo, Japan

Yasushi Abiko