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Nippon Shinyaku Company, Ltd.

Yasuo Yasutomi

Hiroshi Enomoto

Yoshiaki Yoshikuni

Hiromu Murai

Katsuya Ohata

Yukio Fujita

Koji Kitaguchi

Kenji Sempuku

Kohei Kura

Tamiki Mori

Katsuhide Saito

Katsahide Saito

A process for the preparation of amide derivatives of abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid which comprises reacting abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid or a reactive derivative thereof with an amine of the following formula:

Abietamide derivatives, their production and use

Process for the preparation of abietanilides which comprises reacting abietic acid, dihydroabietic acid, tetrahydroabietic acid or a reactive derivative thereof with aniline and the products thereby produced, compositions containing the same for reducing blood serum cholesterol and method of use of such compositions.

Abietanilides, their production and use

Substituted N-phenyl and N-benzyl abietamide derivatives, including the dehydro-, dihydro-, and tetrahydroabietamide derivatives, are cholesterol lowering agents. The abietamide derivatives, of which N-(2,6-dimethylphenyl)-.DELTA..sup.8 -dihydroabietamide is a typical example, are produced by the reaction of abietic acid, dehydroabietic acid, dihydroabietic acid, tetrahydroabietic acid and/or active derivatives thereof with a substituted aniline or benzylamine.

N-(substituted phenyl and benzyl)abietamides

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Umegaoka, Nagaokakyo, Kyoto, undefined

Yasuo Yasutomi