Takiron Co., Ltd.

Other

Ono Pharmaceutical Co., Ltd.

Earth Chemical Co., Ltd.

Biomaterials Universe, Inc.

Yasuo Shikinami

Kunihiro Hata

Kosuke Iida

Masaki Okuno

Hidekazu Boutani

Kaoru Tsuta

Seiei Sasatani

Hiroshi Morii

Masahiko Taniguchi

Yoshito Ikada

Suong-Hyu Hyon

Masao Sudoh

Yoshinobu Yoshikawa

Ryuichi Kimura

Hiroyuki Kawarada

Tetsuya Fujii

Fumio Kasajima

Yutaka Ohmura

Hiroshi Kimura

Chika Nishi

Kiyoshi Utsumi

The forging-reinforced composite constructed of a plurality of different kinds of materials, which have compatible polymers comprising crystalline and glass phases at room temperature for the matrices, is a composite, wherein, by being forged in a layer-separated state in which each of the different kinds of materials forms micron-sized fibrous layers that crossed and intermingled three-dimensionally with each other and the arrangement of the crystals in the crystalline phases configuring the matrices having a disordered orientation without anisotropy in a variety of directions, the inherent-properties of the material of each layer are complementarily reinforced. A mixed nonwoven fabric wherein microfibers are crossed and intermingled two- or three-dimensionally with each other is manufactured and heated under pressure at or above the melting point of the polymers to manufacture compact blocks wherein the microfibers are welded. Then, the compact blocks are forged at a crystallization temperature.

Reinforced composit that is complementarily reinforced and production method therefor

The artificial intervertebral disc of the present invention includes: a structured fabric having biomimetic structure and dynamic behavior, the structure comprising organic fibers, which are formed to be a cubic multi-axial three-dimensional fabric having tri-axial, to be interwoven tissues or to be a complex tissue of these; and tappets mounted on the upper surface and the lower surface of this structured fabric, wherein the tappets are connected and fitted with the connecting filaments vertically penetrating through the structured fabric. This structured fabric shows biomimetic dynamic behavior like a real intervertebral disc and achieves a clinically effective and reliable stand-alone type of biomimetic artificial intervertebral disc which can be inserted and fixed with minimally-invasive operation.

Stand-alone biomimetic artificial intervertebral disc system

The present invention provides an implant material comprising an organic-inorganic complex porous article and a production method thereof. The organic-inorganic complex porous article is a biodegradable and bioabsorbable bioactive porous article in which a bioactive bioceramics powder is uniformly dispersed in a biodegradable and bioabsorbable polymer, wherein it has continuous pores and the bioceramics powder is partly exposed to the pore inner surface or the pore inner surface and the porous article surface.

Implant material and process for producing the same

A process for producing a biodegradable and bioabsorbable implant material, which comprises forging a billet comprising and biodegradable and bioabsorbable crystalline polymer at a low temperature and then forging the same once more or in a plurality of times at a low temperature by changing its press-forcing direction.

Method for adjusting the shape of a biodegradable and bioabsorbable implant material

This invention provides a biodegradable and bioabsorbable implant material having a high mechanical strength wherein its shape after deformation within ordinary temperature range can be fixed and maintained so that its shape can be easily adjusted at the site of operation, and it has substantially no anisotropy in view of strength so that it does not cause whitening, breakage and sharp decrease in strength when its bending deformation is repeated in any direction and it has toughness. Particularly, it provides an implant material which comprises a biodegradable and bioabsorbable crystalline polymer that has a crystallinity of 5% or more, can effect deformation such as bending or twisting within ordinary temperature range and has a shape-keeping ability to fix and maintain the shape after deformation as such, wherein molecular chains, domains of molecular chain assembly or crystals of the polymer are oriented along a large number of reference axes having different axial directions, or clusters having these reference axes having different orientation are assembled in a large number.

Biodegradable and bioabsorbable implant material and method for adjusting shape thereof

This invention provides a claycy and sticky substance as a new biomaterial that cannot be found in the current medical field, which is bioresorbable, shows tackiness, plasticity and shape holding ability at a temperature of approximately from 30 to 40&deg; C. and can give unrestricted shapes at body temperature or more by increasing its fluidity. This clayey and sticky substance comprises a copolymer of two or more bioresorbable monomers, preferably any one of copolymers of p-dioxanone with D-lactic acid, L-lactic acid, D,L-lactic acid, trimethylene carbonate and &egr;-caprolactone, or a mixture of two or more of these copolymers. This clayey and sticky or clayey substance is suited for a hemostatic material, an adhesive material for tissues, a prosthetic material for tissue reconstruction use, a carrier of drug delivery system, a plugging material, an accretion-preventing material and a scaffold material for tissue engineering use.

Bioresorbable polymeric clayey and sticky substance

Shape-memory biodegradable and absorbable materials which make it possible to easily treat vital tissues by suture, anastomosis, ligation, fixation, reconstitution, prosthesis, etc. without causing burn. These materials never induce halation in MRI or CT and never remain in vivo. Such a shape-memory biodegradable and absorbable material is a material made of a molded article of lactic acid-based polymer and can be recovered to the original shape without applying any external force thereto but heating to a definite temperature or above. It is obtained by deforming a molded article (a primary molded article) made of a lactic acid-based polymer and having a definite shape into another molded article (a secondary molded article) having another shape at a temperature higher than the glass transition temperature thereof but lower than the crystallization temperature thereof (or 100&deg; C. when the molded article has no crystallization temperature) and then fixing said molded article to the thus deformed shape by cooling it as such to a temperature lower than the glass transition temperature. When this material is heated to the above-mentioned deformation temperature or above, it is immediately recovered to the original shape. The lactic acid-based polymer is hydrolyzed and absorbed in vivo.

Shape-memory, biodegradable and absorbable material

Material for osteosynthesis and composite implant material, and

A base polymer for transdermal absorption preparation, which is a solid at ordinary temperatures, which becomes a liquid having a low viscosity near the skin temperature of human, which has heat-sensitive and water-sensitive properties as it has a hydrophilic segment, which is capable of stably storing the drug which conventionally has not been easily formulated into a transdermal absorption preparation, and which is capable of effecting transdermal absorption of the drug at a high releasing ratio and yet in a slow-releasing manner with less skin irritation. The base polymer comprises a heat-sensitive segment polyurethane which is represented by the following general formula:

Base polymer for transdermal absorption preparation comprising a

Pressure sensitive adhesives for transdermal absorption formulations comprising a segmented polyurethane, which can control dissolution and a releasing property of drugs of various kinds which are solid at normal temperature; said segment being an alkylene oxide chain which is in a liquid state at a temperature of around normal temperature to around body temperature, and said segment containing a hydrophilic alkylene oxide chain and a hydrophobic alkylene oxide chain, or comprising one or both of them and an alkylene oxide chain in which a hydrophilic moiety and a hydrophobic moiety are present in the mixed manner.

Pressure sensitive adhesive for transdermal absorption formulations

The present invention provides a transdermal absorption preparation whereby a drug, which takes effect with a small amount, and is liable to be decomposed, solid at ordinary temperatures, water-soluble and less absorbable into the skin, can be stored stably for a long period of time and, can be transdermally administered at a high releasing ratio and yet releasing slowly, when applied to the skin. The constitution of the present invention is as follows: a transdermal absorption preparation which comprises a drug-storing layer containing a drug and having a drug-releasing face coated with a drug-releasing controlling membrane, wherein said drug-storing layer comprises as a base a heat-sensitive segmented polyurethane represented by the general formula:

Transdermal absorption preparation

This invention provides an implant material which has high mechanical strength and durability in three-dimensional directions and a function to synchronize with deformation characteristics of surrounding biological tissues, is capable of being penetrated by biological tissues into its fabric space, and does not cause foreign body reaction or can positively connect with biological tissues, so that it can be implanted in the living body for a prolonged period of time. It uses, as a base material, a biocompatible bulk structure of a three-dimensionally woven or knitted fabric of organic fibers or a composite fabric thereof, and its void ratio in the fabric is preferably set to 20 to 90 vol %. More preferably, the surface of organic fibers which constitute the bulk structure is biologically activated or inactivated.

Biocompatible implant material comprising a tri-axial or more

Phase-separated membrane

A polymeric piezoelectric material including a polylactic acid molded article having been uniaxially drawn to an extent causing no fibrillation. The piezoelectric material exhibits piezoelectric properties equal to or higher than those of electret type or polypeptide type piezoelectric materials while having high enough mechanical strength to be processed into various articles ranging from films to profiles depending on the end use.

Polymeric piezoelectric material

Biodegradable and resorbable surgical materials of molded articles of poly(lactic acid) or copolymers of lactic acid and glycolic acid, characterized in that the articles are molecular-orientated, and having a bending strength of 1.6.times.10.sup.33 to 2.5.times.10.sup.3 kg/cm.sup.2, a bending modulus of 5.5.times.10.sup.2 to 24.0.times.10.sup.2 kg/cm.sup.2, a crystallinity, determined by density measurement, of 10 to 60%, and a viscosity average molecular weight measured after melt processing of not less than 200,000, and in that at least 80% of initial strength of the articles is maintained after dipping in a saline at 37.degree. C. for three months.

Growing community of inventors

Osaka, Japan

Yasuo Shikinami